pharm 1 liner- blue high yield

Question 1

H1 antihistamine with 5HT2 antagonist activity that is mostly used for carcinoid tumor but may be used to treat serotonin syndrome

Answer 1

cyproheptadine

Question 2

agent that is metabolized by alcohol dehydrogenase or microsomal ethanol-oxidizing system (MEOS) to acetaldehyde; displays zero order kinetics of elimination

Answer 2

ethanol

Question 3

used for symptomatic treatment of thyrotoxicosis by blocking cardiac adverse effects

Answer 3

beta blockers such as propranolol and esmolol

Question 4

side effect of menicillamine

Answer 4

hypersensitivity (rash), nephrotoxicity, myopathy, myelosuppresion

Question 5

antidote for methotrexate toxicity

Answer 5

leucovorin

Question 6

4 intermediate acting glucocorticoids

Answer 6

prednisone, prednisolone, methylprednisolone, trialcinolone

Question 7

drug of choice indicated for familial or essential tremors

Answer 7

propranolol

Question 8

a centrally acting anticholinergics useful for tremor and rigidity but have little effect on bradykinesia in patients with parkinson

Answer 8

benztropine

Question 9

opioid receptor antagonist used to prevent alcohol abuse

Answer 9

naltrexone

Question 10

dose-limiting toxicity of methotrexate

Answer 10

myelosuppresion

Question 11

drug used concurrently with antineoplastics to reduce renal precipitation of urates

Answer 11

allopurinol

Question 12

competes for alcohol dehydrogenase and is used in methanol or ethylene glycol poisoning

Answer 12

fomepizole, ethanol

Question 13

gonadotropin-releasing hormone agonist that can be used to inhibit luteinizing hormone secretion and testosterone production in men with advanced prostate cancer

Answer 13

leuprolide

Question 14

selective estrogen receptor modulator most commonly used for treatment of breast cancer

Answer 14

tamoxifen

Question 15

antidote for opioid toxicity

Answer 15

naloxone (IV)

Question 16

opioid antagonist that is given orally

Answer 16

naltrexone

Question 17

CNS stimulate that acts by inhibiting reuptake of neurotransmitters; may cause pupil dilation, alter tactile sensation, irregular breathing and cardiac toxicity

Answer 17

cocaine

Question 18

drug for treating malignant hyperthermia associated with drug-drug interaction between halogenated anesthetics and depolarizing blocker

Answer 18

dantrolene

Question 19

2 anthracyclines that chelate DNA, form free radicals, and cause dose-limiting cardiotoxicity

Answer 19

daunorubicin, doxorubicin

Question 20

side effect of nitroprusside

Answer 20

cyanide poisoning

Question 21

long-acting opioids used in the management of withdrawal states

Answer 21

methadone, buprenorphine

Question 22

opioids used for long-term maintenance from opioid withdrawal

Answer 22

methadone, buprenorphine

Question 23

opioid receptor antagonist that is used to treat opioid intoxication, may cause more rapid and intense symptoms of withdrawal

Answer 23

naloxone

Question 24

agent that is used to bind acrolein and prevent drug-induced hemorrhagic cystitis

Answer 24

meson

Question 25

irreversible, nonselective COX inhibitor that displays zero-order kinetics of elimination

Answer 25

aspirin

Question 26

selective estrogen receptor modulator used for prevention of osteoporosis and invasive breast cancer

Answer 26

raloxifene

Question 27

antidote for wilson's disease (copper poisoning)

Answer 27

penicillamine

Question 28

the only local anesthetic with vasoconstrictive property, but due to abuse potential, only occasionally used for nasal surgery

Answer 28

cocaine

Question 29

treatment for drug-induced neuroleptic malignant syndrome

Answer 29

dantrolene

Question 30

antidote for acetaminophen poisoning

Answer 30

N-acetylcysteine

Question 31

iron chelator that is used to protect against anthracycline-induced cradiotoxicity

Answer 31

dexrazoxane

Question 32

side effect of tissue plasminogen activators

Answer 32

cerebral hemorrhage

Question 33

ergot type 2 dopamine receptor (D2) agonist, used as adjunct to improve motor function in parkinsons patients with fluctuations in clinical response

Answer 33

bromocriptine

Question 34

vitamin K dependent anticoagulant with zero order kinetics of elimination

Answer 34

warfarin (PT)

Question 35

recombinant human monoclonal antibody against human epidermal growth factor 2 (HER2) receptor; useful in breast cancer cells that overexposes HER2

Answer 35

trastuzumab

Question 36

side effect of acetaminophen

Answer 36

hepatotoxicity

Question 37

antidote used for warfarin toxicity

Answer 37

vitamin 1 and fresh frozen plasma

Question 38

serious side effect of selective serotonin reuptake inhibitors when used with other drugs such as monoamine oxidase inhibitors, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressants

Answer 38

serotonin syndrome

Question 39

serious side effect of cyclophosphamide and ifosamide due to generation of acrolein

Answer 39

hemorrhagic cystitis

Question 40

ergot dopamine agonist used to suppress prolactin release

Answer 40

bromocriptine

Question 41

antidote used for heparin toxicity

Answer 41

protamine sulfate

Question 42

antidote for TCA (tricycle antidepressants)

Answer 42

sodium bicarbonate (alkalinize plasma)

Question 43

antimuscarinic that treats parkinsonism and extrapyramidal disease

Answer 43

benztropine

Question 44

antidote for cyanide poisoning

Answer 44

nitrites, thiosulfate, hydroxocobalamin

Question 45

2 prodrugs, that after liver bioactivation, bind to N7 nitrogen of guanine and cross-link DNA

Answer 45

cyclophosphamide, ifosamide

Question 46

rare, but fatal side effect associated with combination of halogenated inhalation anesthetic and depolarizing blocker

Answer 46

malignant hyperthermia

Question 47

gonadotropin-releasing hormone analog used for infertility (pulsatile admin) or suppression of gonadotropin production (continuous administration)

Answer 47

leuprolide

Question 48

opioid antagonist that is given IV

Answer 48

naloxone

Question 49

three life-threatening side effects associated with tricyclic antidepressants

Answer 49

convulsions, cardiotoxicity, coma (3 Cs)

Question 50

antidote for methanol and ethylene glycol toxicity

Answer 50

fomepizole, ethanol

Question 51

antidote for benzodiazepine toxicity

Answer 51

flumazenil

Question 52

anti epileptic agent that exhibits zero order kinetics,c causes fetal hydantoin syndrome, and induces CYP450

Answer 52

phenytoin

Question 53

benzodiazepine antagonist used to treat benzodiazepine intoxication

Answer 53

fumazenil

Question 54

side effect of both warfarin and heparin

Answer 54

bleeding

Question 55

agent that inhibits xanthine oxidase and used to treat chronic gout

Answer 55

allopurinol, febuxostat

Question 56

antineoplastic folic acid analog that inhibits dihydrofolate reductase

Answer 56

methotrexate

Question 57

2 most commonly used glucocorticoids for cancer due to their lymphotoxin effects; may cause coshing-like symptoms

Answer 57

prednisone, prednisolone

Question 58

constant amount of drug metabolized per unit time

Answer 58

zero order kinetics

Question 59

antidote for tissue plasminogen activator (t-PA), streptokinase

Answer 59

aminocaproic acid