Pharm 1 Liner- all micro drugs

Question 1

Cheap wide spectrum antibiotic drug of choice for otitis media

Answer 1

Amoxicillin

Question 2

Drug of choice for herpes and its mechanism of action

Answer 2

Acyclovir; activated by viral thymidine kinase, inhibits viral DNA replication

Question 3

Drug of choice for CMV treatment

Answer 3

Ganciclovir

Question 4

Aminoglycosides less used due to its irreversible vestibular toxicity

Answer 4

Streptomycin

Question 5

HIV medication used to reduce mother to child transmission during birth

Answer 5

Zidovudine, nevirapine

Question 6

Antiviral associated with neutropenia

Answer 6

Ganciclovir, zidovudine, interferon

Question 7

Drug of choice for legionnaires disease

Answer 7

Azithromycin and levofloxacin

Question 8

Anti-retroviral class that causes drug interactions by causing inhibition of CYP enzymes

Answer 8

Protease inhibitors

Question 9

Drug of choice for treatment of mild to moderate pseudomembraous colitis

Answer 9

Metronidazole

Question 10

Drug of choice for N. gonorrhea

Answer 10

Ceftriaxone

Question 11

Antiviral/anti-retrieval that are teratogens (2)

Answer 11

Efavirenz, ribavirin

Question 12

Inhibits isoleucine tRNA and used topically for impetigo

Answer 12

Mupirocin

Question 13

Mechanism of action of nystatin

Answer 13

Binds to ergosterol and creates a pore in fungal membrane

Question 14

Adverse effect of ganciclovir

Answer 14

Myelosuppresion (nuetropenia)

Question 15

Mechanism of action of fluoroquinolones

Answer 15

Inhibit DNA gyrase (topoisomerase II) and topoisomerase IV

Question 16

Neurotoxicity with isoniazid can be prevented by

Answer 16

Admin of vitamin B6

Question 17

Mechanism of action of macrolides (erythromycin, clarithromycin)

Answer 17

Inhibit protein synthesis by binding to 23S rRNA of 50S ribosome subunit

Question 18

Mechanism of action of penicillin

Answer 18

Block cell wall synthesis by inhibiting transpeptidase and block peptidoglycan cross linkage

Question 19

2 nucleoside reverse transcriptase inhibitors approved for both HIV and HBV infections

Answer 19

Tenofovir, lamivudine

Question 20

Penicillins active against pseudomonas

Answer 20

Piperacillin and ticarcillin

Question 21

Mechanism of action of vancomycin

Answer 21

Binds to D-Ala-D-Ala on murein monomers and prevent polymerization of the murein monomers

Question 22

Drug notorious for causing pseudomembranous colitis

Answer 22

Clindamycin

Question 23

Drug of choice for influenza A and B

Answer 23

Oseltamivir and zanamivir

Question 24

Mechanism of action of sulfonamides

Answer 24

Inhibit dihydropteroate synthase

Question 25

Beta lactam that can be used in penicillin-allergic patients

Answer 25

aztreonam

Question 26

Drug used for MRSA

Answer 26

Vancomycin

Question 27

Treatment of choice for leprosy

Answer 27

Dapsone and rifampicin

Question 28

Adverse effect of ketoconazole only in men

Answer 28

Gynecomastia

Question 29

Drug causes tooth discoloration

Answer 29

Tetracycline

Question 30

Drug of choice for RSV

Answer 30

Ribavirin

Question 31

Technique used to diagnose perinatal itching, and the drug used to treat infection associated with it

Answer 31

Scotch tape technique and mebendazole (albendazole)

Question 32

Drug used in exoerythrocytic cycle of malaria

Answer 32

Primaquine

Question 33

Meningitis prophylaxis in exposed patients

Answer 33

Rifampin

Question 34

Common adverse effect of rifampin

Answer 34

Orange urine discoloration

Question 35

First line for treatment of chronic HCV infections in genotype 1 patients

Answer 35

IFN plus ribavirin plus protease inhibitor (-previr)

Question 36

Antibacterial that cause hemolysis in G6Pd deficient patients

Answer 36

Sulfonamides

Question 37

Antibiotic causing red nan syndrome

Answer 37

Vancomycin

Question 38

Penicillins activate against penicillinase secreting bacteria (4)

Answer 38

Methicillin, nafcillin, oxacillin, dicloxacillin

Question 39

Mechanism of action of tetracycline

Answer 39

Decreases protein synthesis by binding to 30s ribosome and prevent binding of tRNA

Question 40

Drug that causes gray baby syndrome and aplastic anemia

Answer 40

Chloramphenicol

Question 41

Anti-retroviral class that causes drug interactions by causing induction of CYP enzymes

Answer 41

Non-nucleoside/tide reverse transcriptase inhibitors

Question 42

Anti-retroviral with a dose limiting toxicity of pancreaatitis and peripheral neuropathy

Answer 42

Didanosine

Question 43

Drug of choice for treatment of serious pseudomembraous colitis

Answer 43

Oral vancomycin

Question 44

Drug of choice for giardia, entamoeba, pseudomembranous colitis, and trichomonas

Answer 44

Metronidazole

Question 45

2 toxicities of aminoglycosides

Answer 45

Nephro and ototoxicity

Question 46

Toxicity of amphotericin B

Answer 46

Nephrotoxicity

Question 47

Anemia caused by trimethoprim

Answer 47

Megaloblastic anemia

Question 48

Adverse effects of isoniazid (3)

Answer 48

SLE-like erythematosus, peripheral neuritis, hepatitis

Question 49

Three anti-retroviral agents associated with fatal Stevens Johnson syndrome

Answer 49

Nevirapine, efavirenz, etravirine

Question 50

Reason fluoroquinolones are contraindicated in children and pregnancy

Answer 50

Cartilage damage

Question 51

Adverse ffect of metronidazole when given with alcohol

Answer 51

Disulfiram-like reaction

Question 52

Adverse effect of imipenem

Answer 52

Seizures

Question 53

Class of antibiotics that have 10% cross sensitivity with penicillins

Answer 53

Cephalosporins

Question 54

Quadruple therapy for treatment of TB

Answer 54

Rifampin, isoniazid, pyrazinamide, and ethambutol

Question 55

First line for treatment of HBV infections

Answer 55

IFN and NRTI