Fiser Chapter 3 BLOOD PRODUCTS Flashcards Preview

ABSITE > Fiser Chapter 3 BLOOD PRODUCTS > Flashcards

Flashcards in Fiser Chapter 3 BLOOD PRODUCTS Deck (26):
1

Blood products that carry risk of HIV and hepatitis

All except albumin and serum globulins

2

Donated blood is screened for what

HIV
HepB
HepC
HTLV
Syphilis
West Nile virus

3

Who gets CMV negative blood

Low birth weight infants
BM transplant and other transplant patients

4

MCC death from transfusion reaction

Clerical error leading to ABO incompatibility

5

Type O blood

Universal donor, no Ag

6

Type AB blood

Contains both A and B antigens

7

Stored blood left shift due to

Low 2,3-DPG
(Increased affinity for O2)

8

Hemolysis reactions

-Acute hemolysis

-Delayed hemolysis

-Nonimmune hemolysis

9

Other reactions (non-hemolytic)

-Febrile nonhemolytic

-Anaphylaxis

-Urticaria

-TRALI

10

ABO incompatibility causes what kind of reaction?

Acute hemolysis, Ab-mediated

-Back pain, chills, tachy, fever, hemoglobinuria
-Can lead to ATN, DIC, shock
-Haptoglobin <50, free Hgb >5, increased unconjugated bili
-Tx: fluids, diuretics, HCO3-, pressors, histamine blockers (Benadryl)
-In anesthetized patients, may present as diffused bleeding

11

Tx of acute hemolytic transfusion rxn

(Caused by ABO incompatibility)
-Fluids, diuretics, HCO3-, pressors, benadryl

12

Patient getting transfusion develops back pain, chills, tachycardia, fever, hemoglobinuria

Acute hemolysis from ABO incompatibility
-In anesthetized patient may present as diffuse bleeding

13

Delayed hemolysis

Ab-mediated against minor antigens
Tx: observe if stable

14

Nonimmune hemolysis

From squeezed blood
Tx: fluids and diuretics

15

Febrile nonhemolytic transfusion reaction

-Most common transfusion reaction
-Usually recipient Ab against donor WBCs
-Tx: Stop transfusion if previous transfusions or if occurs soon after transfusion begun
-Use WBC filters for subsequent transfusions

16

Most common transfusion reaction

Febrile nonhemolytic transfusion reaction (recipient Ab to donor WBCs)

17

Anaphylaxis transfusion reaction

-Bronchospasm, hypotension, urticarial
-Usually recipient Ab against donor IgA in IgA-deficient recipient
-Tx: Fluids, Lasix, pressors, steroids, epinephrine, histamine blockers (Benadryl)

18

Patient getting blood transfusion develops hypotension, bronchospasm, urticaria

Anaphylaxis
-IgA deficient recipient has Ab against donor IgA

19

Uricaria transfusion reaction

-Usually nonhemolytic
-Usually recipient Ab against donor plasma proteins or IgA in IgA-deficient patient
-Tx: Histamin blockers (Benadryl), supportive

20

TRALI

-Rare
-Donor Ab to recipient WBC (opposite of febrile nonhemolytic transfusion reaction) -> clot in pulmonary capillaries

21

Recipient Ab against donor WBCs

Febrile nonhemolytic transfusion reaction

22

Donor Ab against recipient WBCs

TRALI

23

ABO incompatibility causes what

Acute hemolytic transfusion reaction

24

Massive transfusion side effects

-Dilutional thrombocytopenia after 10 units pRBCs
-Hypocalcemia -> poor clotting

25

Most common bacterial contaminate of blood

GNRs (e coli)

26

Most common blood product source of contamination

Platelets (not refridgerated)