Flashcards in Francisella, Coxiella, Legionella Deck (17)
What is the one species of Francisella we are concerned with?
Fracisella is the cause of what?
tularemia or rabbit fever
The biovar ______ is found only in North America
Francisella biovar ________ is distributed more widely and is fevered to as ______ fever as it is associated with this animal
Francisella biovar _____ is a cause of human disease
What are the hosts for biovar tularensis and biovar palaeartica?
tularensis: ticks, wild rodents, and rabbits
What is the only way Francisella is spread to humans?
Via contact with rabbit or beaver/rodent
Via deer fly or tick bite (most common)
T/F The infectious dose of Francisella is very low
What is the route of infection of Francisella?
It gets in via an abrasion and goes to the LNs
Then migrates to liver, spleen, BM, forming granulomatous nodules which can ulcerate
What are the drugs you would use to treat Francisella?
Streptomycin or Gentomycin
What is the species of Coxiella we are concerned with?
Coxiella burnetii is an _________ bacterium that is closely related to _______ and Legionella
Coxiella burnetii is the cause of ____ in humans and ______ in ruminants
abortions and respiratory tract infections
What are the two phases of Coxiella burnetii and what is a unique feature of each?
Phase I: Highly infective
Phase II: less infective, appear when culutres are repeatedly passed through egg or tissue culture
Antibody against Phase ___ of Coxiella burnetii often appears first
What is the primary importance of disease for Coxiella burnetii? What do ruminants shed it in?
Contamination of meat/milk causing infection of humans
Ruminants shed it in milk, urine, feces, and esp the placenta