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Flashcards in Helicobacter/Clostridia Deck (104)
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1

______ is associated with acute gastritis and duodenal ulcers in humans

Helicobacter pylori

2

______ has been isolated from gastric mucosa of humans, cats dogs and pigs

Helicobacter heilmannii

3

______ is a common cause of gastric ulcers in ferrets

Helicobacter mustelae

4

______ , ______ , and ______ are from humans and may be clinically important assocaited with diarrhea

H. cinaedi
H. canis
H. fennelliae

5

______ , ______ . and ______ isolated from the bilary tract of rodents and humans play a possible role in cholecystitis and cancer of the gall bladder

H. bilis
H. hepaticus
H. pullorum

6

The ______ genome has been sequenced

Helicobacter pylori

7

______ has been isolated from multpile cases of acute gastritis after gastric endoscopy

Helicobacter pylori

8

______ generates ammonimum ions and CO2 that are responsible for much of the tissue damage in Helicobacter infections

Urease enzyme

9

T/F Helicobacter organisms are highly antibiotic resistant

FALSE susceptible to a number of drugs

10

T/F Clostridium are facultative anaerobes

FALSE- they are obligate anearobes

11

What are the 2 broad types of clostridia?

Those that do not actively invade/multiply

Those that do invade and multiply in the tissue

12

T/F Clostridia that actively invade tissue and multpily are also known as the gas gangrene group

True

13

T/F C. botulinum is an example of a gas gangrene clostridia

False, it is a member of the other group

14

______ and ______ are Clostridia that do not actively invade tissue/multiply rely solely on toxin production at localized sites or in vitro.

C. Tetani and C. botulinum

15

What is the habitat of C. tetani?

soil, fecal material, readily found in horse and human feces

16

T/F There are several serotypes of Clostridium tetani that are significantly important

FALSE only the toxin is of clinical significance

17

______ is the toxin of C. tetani that is responsible for clinical disease

Tetanosporin

18

Tetanosporin block ______ release specifically ______ and ______ at the level of the brainstem and spinal cord

neurotransmitter
glycine and gamma-aminobutyric acid

19

What are the clinical signs associated with tetanosportin?

continuous spasms of opposing muscle groups- tentany

20

T/F once the tetanus toxin binds to gangliosides it is easily reversible

FALSE it is almost irreversible and antibody is not effective once it is bound

21

______ produces local necrosis and thereby stimulates the growth of C. tetani

Hemolysin

22

______ binds to the nueromuscular junction but its function is unknown

Non-spasmogenic toxin

23

Give a brief pathogensis of Clostridium tetani

organism/usually the spre form enters would/tissue w/ low oxygen tension

deep wounds usually innoculated w/ contmainating bacteria which cause necrosis in the surrounding tissues, reduce the O2 tension and allow growth/germination of C. tetani

Toxin Spreads along the peripheral nerves or hematogenous and through the lymph

24

What is ascending tetanus?

Term form tetanus toxin affecting those nerves closest to the lesion

25

What is descending tetanus?

when toxin spreads through the lymph- classic lock jaw

nerves affected first are those that are most sensitive- horses and humans usually get this

26

______ use has led to an increase reports of tetanus in calves

elastrator band

27

______ is given to provide immediate passive immunity following and injury followed by or given simultaneously w/ the ______ to prevent tetanus

Antitoxin; toxoid

28

______ is a relatively rare cause of food poisoning in humans, domestic animals and waterfowl

Clostrium botulinum

29

______ was associated with an outbreak in CA w/ intravenous black tar heroin users

Clostridium botulinum

30

______ is relatively common form of botulinum in children

Toxico-infectious botulism OR
infant botulism