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Flashcards in fungal infection 2 Deck (15)
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1

what is the morbidity and mortality rate of disseminated candidiasis

30-60%

2

what are the 3 distinct presentations of disseminated candidiasis (the first of these contains 5)

1. acute onset of fever, tachycardia, tachypnea, chills and hypotension
2. intermittent fevers and are only ill when febrile
3. manifest progressive deterioration of their conditions with or without fever

3

where are lab diagnosis of candidiasis often cultured from in and potentially infected patients

urine and respiratory tract

4

what drugs work best for C. glabrata

echinocandins (ampho too, but can have intermediate resistance)

5

what is the difference in candiaisis and candidemia

candidiasis = spreading infection
candidemia = bloodstream infection
treat the same

6

what is primary therapy for candidiasis/ candidemia in nonneutropenic adults

fluconazole or echinocandin

7

what is primary therapy for candidiasis/ candidemia in neutropenic adults

echinocandin or lipid formulation of amphotericin

8

what is primary therapy for chronic disseminated candidiasis

fluconazole or amphotericin (for several weeks, followed by transition to fluconazole)

9

what should be chosen for moderately ill to severely ill candidiasis/ candidemia patients, or patients with recent azole exposure

echinocandin

10

for chronic dissimenated candidiasis. what should be initiated in stable patients

fluconazole

11

for chronic dissimenated candidiasis. what should be initiated in severe patients

amphotericin for a couple weeks

12

If someone is on empiric therapy, candidiasis should be assumed after how long a period of antibiotic therapy

4 days; sooner if risk factors present

13

what is the minimum treatment duration for candidiasis

14 days after first negative culture

14

what should be done with pt.s with IV lines who are determined to have candidiasis/ candidemia

remove any IV catheters

15

all patients with candidemia need what non pharm monitoring? what is this looking for

eye exam
to rule out candida endophthalmitis