Flashcards in fungus 4 Deck (20)
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1
what are the 3 common pathogenic species of aspergillosis
1. aspergillus fumigatus (most common)
2. aspergillus flavus
3. aspergillus niger
2
the spectrum of diseases of aspergillosis is attributed to what factors?
1. allergy
2. colonization
3. tissue invasion
3
aspergillosis can be found where
everywhere; but ubiquitous in the environment
4
if aspergillosis colonization is a problem in what type of patients
1. asthma
2. cystic fibrosis
3. chronic sinusitis
4. chronic obstructive airway disease
5. cavitary lung disease
5
If an aspergillosis infection colonizes and becomes invasive what can occur
1. acute pneumonia
2. chronic necrotizing pneumonia
3. dissemination
6
who is at risk for aspergilloma (ball of fungus sitting in lung)
chronic sinusitis
chronic obstructive airway disease
cavitary lung disease
7
what are the risk factors for allergic bronchopulmonary aspergillosis
cystic fibrosis and asthma
8
what are the risk factors for aspergilloma
underlying lung diseases:
chronic sinusitis
chronic obstructive airway disease
cavitary lung disease
9
what are the risk factors for invasive aspergillosis
immunocompromised status
10
what are the risk factors for chronic pulmonary aspergillosis
underlying lung disease
11
what are the risk factors for superficial aspergillus infections
immunocompromised status
12
what are the problems for cultures when diagnosing aspergillosis
cultures are often false negatives
13
what is a helpful diagnosis tool for aspergillosis
galactomannan antigen test
(very sensitives so negative = safe; positive = maybe)
14
what is the treatment for invasive pulmonary aspergillosis (IPA)
voriconazole
15
what is the treatment for invasive sinus aspergillosis
voricaonazole
16
what is the prophylactic therapy for invasive aspergillosis
posaconazole
17
what is the treatment for chronic cavitary pulmonary aspergillosis
itraconazole or voriconazole
18
what is the treatment for allergic bronchopulmonary aspergillosis (no infection; allergic reaction)
itraconazole
19
what is the treatment for aspergilloma
no therapy; surgical intervention may be required
20
