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Flashcards in fungus 4 Deck (20)
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1

what are the 3 common pathogenic species of aspergillosis

1. aspergillus fumigatus (most common)
2. aspergillus flavus
3. aspergillus niger

2

the spectrum of diseases of aspergillosis is attributed to what factors?

1. allergy
2. colonization
3. tissue invasion

3

aspergillosis can be found where

everywhere; but ubiquitous in the environment

4

if aspergillosis colonization is a problem in what type of patients

1. asthma
2. cystic fibrosis
3. chronic sinusitis
4. chronic obstructive airway disease
5. cavitary lung disease

5

If an aspergillosis infection colonizes and becomes invasive what can occur

1. acute pneumonia
2. chronic necrotizing pneumonia
3. dissemination

6

who is at risk for aspergilloma (ball of fungus sitting in lung)

chronic sinusitis
chronic obstructive airway disease
cavitary lung disease

7

what are the risk factors for allergic bronchopulmonary aspergillosis

cystic fibrosis and asthma

8

what are the risk factors for aspergilloma

underlying lung diseases:
chronic sinusitis
chronic obstructive airway disease
cavitary lung disease

9

what are the risk factors for invasive aspergillosis

immunocompromised status

10

what are the risk factors for chronic pulmonary aspergillosis

underlying lung disease

11

what are the risk factors for superficial aspergillus infections

immunocompromised status

12

what are the problems for cultures when diagnosing aspergillosis

cultures are often false negatives

13

what is a helpful diagnosis tool for aspergillosis

galactomannan antigen test
(very sensitives so negative = safe; positive = maybe)

14

what is the treatment for invasive pulmonary aspergillosis (IPA)

voriconazole

15

what is the treatment for invasive sinus aspergillosis

voricaonazole

16

what is the prophylactic therapy for invasive aspergillosis

posaconazole

17

what is the treatment for chronic cavitary pulmonary aspergillosis

itraconazole or voriconazole

18

what is the treatment for allergic bronchopulmonary aspergillosis (no infection; allergic reaction)

itraconazole

19

what is the treatment for aspergilloma

no therapy; surgical intervention may be required

20

what aspergillus relatedconditions is voriconazole the primary therapy

1. IPA (invasive pulmonary aspergillosis)
2. invasive sinus aspergillosis
3. tracheobronchial aspergillosis
4. chronic necrtizing pulmonary aspergillosis
5. CNS aspergillosis