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Flashcards in infective endocarditis 3 Deck (14)
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1

what is the recommended treatment for patients with a prosthetic valve or native valve with a intrinsic penicillin resistance enteroccocal IE, and duration

Vanc for 6 weeks
PLUS
Gent for 6 weeks

2

when is gentamicin mandatory

for enterococcal IE (unless resistant)

3

what is the recommended treatment for patients with a prosthetic valve or native valve with no penicillin resistance enteroccocal IE, and duration

ampicillin or penicillin G for 4-6 weeks
PLUS
Gentamicin for 4-6 weeks

4

what is the recommended treatment for patients with a prosthetic valve or native valve with no penicillin resistance enteroccocal IE, but unable to tolerate beta lactam antibiotics; and duration

Vanc for 6 weeks
PLUS
Gent for 6 weeks

5

what is the recommended treatment for patients with a prosthetic valve native valve with gentamicin resistance resistance enteroccocal IE, and duration

ampicillin or penicillin G for 4-6 weeks
PLUS
streptomycin for 4-6 weeks

6

what is the recommended treatment for patients with a prosthetic valve or native valve with gentamicin resistance resistance enteroccocal IE, but unable to tolerate beta lactam antibiotics; and duration

Vanc for 6 weeks
PLUS
streptomycin for 6 weeks

7

what is the recommended treatment for patients with a prosthetic valve or native valve with penicillin, aminoglycoside, and vancomycin resistance enterococcus faecium IE, and duration

linezolid for 8 weeks or longer
or
quinupristin-dalfopristin for 8 weeks or longer

8

what is the recommended treatment for patients with a prosthetic valve or native valve with penicillin, aminoglycoside, and vancomycin resistance enterococcus faecalis IE, and duration

imipenem/ cilastatin plus ampicillin for 8 weeks or longer
or
ceftriaxone plus ampicillin for 8 weeks or longer

9

what must be monitored when treating resistant enterococcus faecium with linezolid

thrombocytopenia

10

when does treatment duration start when treating IE

from 1st day of negative blood culture

11

what needs to be monitored when treating IE

renal function (especially with aminoglycosides > 1 week)
vancomycin and aminoglycoside concentrations

12

what is the goal vancomycinn trough when treating IE

15-20

13

what is the goal gentamicin trough and peak when treating IE

trough= less than 1
peak = 3-5
(synergistic dosing)

14

what bacteria most commonly cause native aortic valve endocarditis

staph, strep, and enterococci