General - Ch. 13 Flashcards Preview

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Flashcards in General - Ch. 13 Deck (30):
1

Causes of lymphopenia

HIV, glucocorticoids, chemo, autoimmune disorders, malnutrition, some acute viral infections

2

Splenomegaly leads to...

Neutropenia and thrombocytopenia, maybe anemia

3

Most common cause of agranulocytosis

Drug toxicity (chemo drugs or sulfonamides)

4

LGL leukemia...what is it? Side effect?

Monoclonal proliferation of large granular lymphocytes causes feedback suppression of granulocytic precursors, causing neutropenia

5

Ulcerating necrotizing lesions of gingiva, floor of mouth, buccal mucosa, pharynx, or other part of oral cavity...think what? Causes?

Agranulocytosis - via chemo drugs, sulfonamides, aplastic anemia, infiltrative marrow disorders, megaloblastic anemia, myelodysplastic syndromes, Kostmann syndrome

6

Infection w/ massive organismal growth and little leukocytic response. Bacteria growing in colonies

Botryomycosis - due to neutropenia

7

4 major causes (general) of leukocytosis

- Increased production in marrow
- Increased release from marrow stores
- Decreased margination in capillary beds
- Decreased extravasation into tissues

8

Causes of leukocytosis due to increased production in marrow

- Chronic inflammation/infection
- Paraneoplastic response (HL, etc.)
- Myeloproliferative disorder (CML, etc.)

9

Causes of leukocytosis due to increased release from marrow stores

- Endotoxemia
- Infection
- Hypoxia

10

Causes of leukocytosis due to deceased margination in capillary beds

Exercise, catecholamines

11

Cause of leukocytosis due to decreased extravasation into tissues

Glucocorticoids

12

Neutrophilic leukocytosis...think?

- Pyogenic infection
- Tissue necrosis (MI, burns) - sterile inflammation

13

Eosinophilic leukocytosis...think?

Allergies, parasites, drug reactions, some lymphomas, autoimmune disorders, IBD, vasculitides

14

Basophilic leukocytosis...think?

Myeloproliferative disease (CML)

15

Monocytosis...think?

Chronic infections (TB), endocarditis, rickettsia, malaria; autoimmune disorders, IBD

16

Lymphocytosis...think?

Viral infections, Bordetella pertussis, chronic infections (TB, Brucellosis)

17

Severe infection, many immature granulocytes in the blood

Leukemoid reaction - NOT neoplastic

18

Highly dynamic structures in which B cells acquire the capacity to make high-affinity antibodies against specific antigens

Germinal centers - LNs

19

Cervical lymphadenitits, infection symptoms

Acute nonspecific lymphadenitis - teeth or tonsil infection

20

Axillary lymphadenitits, infection symptoms

Acute nonspecific lymphadenitits - extremity infection

21

Mesenteric lymphadenitis, infection symptoms

Acute appendicitis

22

Acute general lymphadenopathy, infection symptoms

Systemic viral infection or bacteremia

23

Naive B cells...neoplasm(s)?

CLL/SLL

24

Mantle B cells...neoplasm(s)?

Mantle cell lymphoma

25

Germinal center B cells...neoplasm(s)?

- Follicular lymphoma
- Burkitt lymphoma
- DLBCL
- Hodgkin's lymphoma

26

Marginal B cells...neoplasm(s)?

- DLBCL
- Marginal zone lymphoma
- CLL/SLL

27

All peripheral T cell lymphomas (not T-ALL) come from what cell type?

Peripheral T cells (paracortical region)

28

Good prognosis in ALL (5)

- 2-10 yo
- Low WBC count (peripheral blasts less than 100,000)
- Hyperdiploidy
- Trisomy of 4, 7, 10
- t(12;21)

29

How to diagnose AML?

Stains for myeloid-specific antigens

30

Common features of MPD's

- Increased BM proliferation
- Extramedullary hematopoiesis
- Marrow fibrosis and cytopenias (spent phase)
- Acute leukemia transformation