Flashcards in Managing Chemo Complications - Fitz Deck (21):
2 main ways to cause N/V from chemo
- Direct activation of medullary CTZ
- 5-HT3 release via damaged enterochromaffin cells (GI)
5-HT3 receptor antagonists
Acute CINV - PRIMARY THERAPY FOR THIS
D2 (central) receptor antagonist
Neurokinin-1 receptor antagonists
Acute or delayed CINV
Cannabinoid CB1 receptor agonist
Side effect of -setron
QT prolongation (EKG changes)
Aprepitant blocks the binding of what substance?
Substance P (to the NK1 receptor)
Delayed emesis is most common after what?
Receptors in the CTZ
5HT-3, D2, NK1
Receptors in the vagal afferent (associated w/ N/V)
Which of the 3 receptor blockers does NOT act on vagal afferents?
Metoclopramide (D2 receptor antagonist)
Treatment regimen for high CINV risk
-setron, Aprepitant, Dexamethasone
Treatment regimen for moderate CINV risk
Treatment regimen for low CINV risk
Treatment for anticipatory emesis
GABA-A receptor (Cl- channel) agonist/potentiator = hyperpolarization, relaxation
Treatment for Cyclophosphamide-induced hemorrhagic cystitis
MoA and when?
PROPHYLACTIC anti-toxin for acrolein
Side effects of MESNA
Hypersensitivity, bad sulfur smell (GI distress)
Blunting agent for Doxorubicin cardiotoxicity
Chelates iron-induced free radicals