Managing Chemo Complications - Fitz Flashcards Preview

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Flashcards in Managing Chemo Complications - Fitz Deck (21):
1

CHOP regimen

NHL

2

ABVD regimen

HL

3

2 main ways to cause N/V from chemo

- Direct activation of medullary CTZ
- 5-HT3 release via damaged enterochromaffin cells (GI)

4

-setron

Use?

5-HT3 receptor antagonists

Acute CINV - PRIMARY THERAPY FOR THIS

5

Metoclopramide

Use?

D2 (central) receptor antagonist

Acute CINV

6

-pitant

Use?

Neurokinin-1 receptor antagonists

Acute or delayed CINV

7

Dronabinol

Use?

Cannabinoid CB1 receptor agonist

Refractory CINV

8

Side effect of -setron

QT prolongation (EKG changes)

9

Aprepitant blocks the binding of what substance?

Substance P (to the NK1 receptor)

10

Delayed emesis is most common after what?

Treatment?

Cisplatin

Aprepitant

11

Receptors in the CTZ

5HT-3, D2, NK1

12

Receptors in the vagal afferent (associated w/ N/V)

5HT-3, NK1

13

Which of the 3 receptor blockers does NOT act on vagal afferents?

Metoclopramide (D2 receptor antagonist)

14

Treatment regimen for high CINV risk

-setron, Aprepitant, Dexamethasone

15

Treatment regimen for moderate CINV risk

-setron, Dexamethasone

16

Treatment regimen for low CINV risk

Dexamethasone

17

Treatment for anticipatory emesis

MoA

Benzo (Lorazepam)

GABA-A receptor (Cl- channel) agonist/potentiator = hyperpolarization, relaxation

18

Treatment for Cyclophosphamide-induced hemorrhagic cystitis

MoA and when?

MESNA

PROPHYLACTIC anti-toxin for acrolein

19

Side effects of MESNA

Hypersensitivity, bad sulfur smell (GI distress)

20

Dexrasoxane

MoA

Blunting agent for Doxorubicin cardiotoxicity

Chelates iron-induced free radicals

21

Amifostine

MoA

Requires what?

Blunting agent for Cisplatin nephrotoxicity

Chelates toxic metabolites and ROS

Activation by alkaline phosphatase