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Heme/Lymph 2 > Hubbard > Flashcards

Hubbard Flashcards

(45 cards)

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1
Q

TTP - treatment

A

Plasmapheresis

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2
Q

vWD presents as ____

A

Mucocutaneous bleeding

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3
Q

Treatment for vWD

A

Cryoprecipitate (vWF) + DDAVP (release vWF)

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4
Q

Vitamin K deficiency - labs

A

Prolonged PT, deficient factors 2, 7, 9, 10, C, S

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5
Q

Treatment for vitamin K deficiency

A

Normal liver fxn – vitamin K supplements

Liver disease or acute hemorrhage – FFP

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6
Q

Hereditary hemorrhagic telangiectasia - gene deficiency

A

Endoglin (CD 105)

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7
Q

Function of antithrombin 3

A

Serine protease - inhibits thrombin activation

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8
Q

AT3 requires what?

A

Heparin

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9
Q

AT3 deficiency causes increased risk of _____

A

Clotting (via thrombin activation)

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10
Q

AT3 deficiency - presentation

A

Recurrent LE thrombophlebitis, DVT, leg ulcers, PE

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11
Q

AT3 deficiency - treatment

Refractory?

A

Anticoagulants (heparin)

AT3 replacement

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12
Q

Protein C/S deficiency - treatment

A

Warfarin

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13
Q

Factor V Leiden - risk?

Treatment?

A

Thromboembolism

No episodes = monitor, etc.

Prior episode(s) = lifelong anticoagulation

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14
Q

Prothrombin 20210

Risk?

A

G-A mutation, causing increased prothrombin activity

Thrombosis

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15
Q

Common occurrences w/ antiphospholipid syndrome

A
  • Thromboembolism
  • Miscarriage
  • Thrombocytopenia
  • Cerebral ischemia/stroke
  • UBOs on MRI
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16
Q

Diagnosis of antiphospholipid syndrome (3)

A
  • Prolonged PTT
  • No correction using normal plasma
  • Neutralization w/ excess phospholipid
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17
Q

Specific diagnostic test for antiphospholipid syndrome

A

Dilute Russell viper venom time (DRVVT)

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18
Q

Treatment for antiphospholipid syndrome

A

Hx of thromboembolism –> lifelong anticoagulation

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19
Q

ITP - treatment

20
Q

Reactive leukocytosis, thrombocytopenia, prolonged PT and PTT, no RBC fragments on smear

How to diagnose?

Study These Flashcards
A

DIC - from infection

Dx = D-dimer level

21
Q

DIC treatment

Study These Flashcards
A

Treat the cause, FFP, cryoprecipitate, platelet transfusions

22
Q

Hyaline thrombi that occlude the capillaries of basically every organ

23
Q

Patient on prolonged antibiotics, PT starts to get longer

Study These Flashcards
A

Vitamin K deficiency - no microbial production

24
Q

Connective tissue disease, prolonged PTT that doesn’t correct, valvular heart disease, recurrent stroke, thrombocytopenia

Study These Flashcards
A

Antiphospholipid syndrome

25
Superficial venous thrombosis - risk?
DVT, PE
26
Oral contraceptives - risk (when combined w/ other disorders)?
Thrombosis
27
Erythromelalgia - treatment
Aspirin
28
SPEP gamma spike w/ hump after Treatment?
MGUS NO treatment, just monitor
29
Solitary plasmacytoma - treatment
Local radiation
30
Multiple myeloma - diagnosis What not to do?
Skeletal survey NOT A BONE SCAN
31
Multiple myeloma - treatment
Thalidomide/lenolidamide + dexamethasone
32
Sausage-linking of fundoscopic veins
Waldenstrom's hyperviscosity
33
Waldenstrom's - treatment
Plasmapheresis, hydration, bisphosphonate
34
Fat pad = green birefringence on congo red
Amyloidosis
35
Joint pain, infections, anemia, bleeding, pedal edema | Multinucleate plasma cells w/ Dutcher bodies in BM
Amyloidosis (AL - light chain)
36
Temporal muscle wasting, chronic diarrhea, pre-renal disease, malabsorption Treatment?
Alpha heavy chain disease Antibiotics
37
Aplastic anemia - treatment
Cyclosporin + anti-thymocyte globulin
38
Diffuse rash, hemolytic anemia, elevated ESR, Gimsa stain Classic finding?
Babesiosis Maltese cross
39
Oral contraceptives + Factor V Leiden
35x increased risk of hypercoaguability
40
Hydroxyurea
Increased HbF in sickle cell
41
Acute chest syndrome - treatment
Transfusion
42
Treatment for PCV and ET
IFN-alpha, phlebotomy
43
Black water fever
RBC burst into blood (malaria complication) - hemoglobinuria and bilirubinuria (direct and indirect)
44
Neuropathy, HSM, endocrine issue, M spike, skin and skeletal lesions
POEMS syndrome - osteosclerotic myeloma
45
Male, eczema, thrombocytopenia, bloody diarrhea, recurrent infections
Wiskott-Aldrich (congenital thrombocytopenia)

Heme/Lymph 2 (16 decks)

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