Treatments and Prognoses Flashcards
1
Q
Hereditary spherocytosis - treatment
Issue?
A
Splenectomy - for anemia
Increased sepsis risk
2
Q
Sickle cell - diagnostic lab procedures
A
Metabisulfite - induces sickling
Hemoglobin electrophoresis
Fetal DNA analysis
3
Q
Sickle cell - treatment
Results of treatment?
A
Hydroxyurea - inhibits DNA synthesis
- Increases HbF, inhibits leukocytes (inflammation)
- These cause decreased crises
4
Q
PNH - diagnosis
A
Flow cytometry for CD59, etc.
5
Q
PNH - initial treatment
Drawback?
A
Eculizumab - C5 activation inhibitor
- Increased risk of meningococcal infections
6
Q
PNH - cure
A
HSC transplantation
7
Q
Warm antibody hemolysis - treatment
A
Remove drug, immunosuppression, or splenectomy
