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Heme/Lymph 2 > Presentations - Ch. 13 > Flashcards

Presentations - Ch. 13 Flashcards

1
Q

Enlarged, painful lymph nodes that may be fluctuant, overlying skin is red

A

Acute nonspecific lymphadenitits - bacterial infection

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2
Q

Enlarged, nontender inguinal and/or axillary lymph nodes that grow slowly over time, organized collections of immune cells in nonlymphoid organs (tertiary lymphoid organs)

A

Chronic nonspecific lymphadenitits - chronic H. pylori gastritis or RA B-cell follicles in synovium

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3
Q

Child, abrupt onset, fatigue, fever, bleeding, bone pain, lymphadenopathy, organomegaly, meningitis symptoms (stiff neck, vomiting, etc.)

Explain symptoms

A

B-ALL (leukemia)

Fatigue = anemia
Fever = neutropenic infections
Bleeding = thrombocytopenia
Bone pain = marrow expansion
Organomegaly and neuro symptoms = neoplastic infiltration
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4
Q

Adolescent male, thymic mass, superior vena cava syndrome, Horner’s syndrome

A

T-ALL (lymphoma)

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5
Q

Adolescent/young adult, masses in the mandible and abdominal viscera

A

Endemic (EBV-associated) Burkitt lymphoma

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6
Q

Older adult, rapidly growing masses within LN, liver, spleen, Waldeyer ring (throat) and/or extranodal sites (GI, skin, bone, brain)

A

DLBCL

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7
Q

Adult, chronic inflammatory disease, extranodal mass, indolent

A

Extranodal marginal zone lymphoma

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8
Q

Middle age, generalized painless lymphadenopathy, marrow involvement, indolent, expanded white pulp follicles in spleen

A

Follicular lymphoma

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9
Q

Middle aged white male, pancytopenia, massive splenomegaly, atypical Mycobacterium infections

A

Hairy cell leukemia

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10
Q

Older male, disseminated disease, moderately aggressive

A

Mantle cell lymphoma

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11
Q

Older adult, lytic bone lesions, pathologic fractures, hypercalcemia, renal failure, neurologic manifestations, recurrent bacterial infections

A

Multiple myeloma

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12
Q

Isolated plasma cell mass in bone, extraosseous lesions in lungs, oronasopharynx, or nasal sinuses

A

Solitary plasmacytoma

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13
Q

Older adult, asymptomatic at diagnosis, then nonspecific symptoms (easily fatigued, weight loss), generalized lymphadenopathy, hepatosplenomegaly, periportal lymphocytic infiltrate in liver

A

CLL/SLL

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14
Q

Adult, rapidly progressive, skin lesions, generalized lymphadenopathy, hepatosplenomegaly, lymphocytosis, hypercalcemia

What else can accompany this?

A

Adult T cell leukemia/lymphoma - Endemic to Japan, West Africa, Caribbean

Progressive demyelinating disease

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15
Q

Older adult, generalized lymphadenopathy, eosinophilia, pruritis, fever, weight loss

A

Peripheral T-cell lymphoma, unspecified

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16
Q

Children/young adult, LN and soft tissue disease

A

Anaplastic large-cell lymphoma

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17
Q

Adult, destructive extranodal mass (esp. sinonasal, testis, or skin), ischemic necrosis, EBV

A

Extranodal NK/T-cell lymphoma

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18
Q

Adult, changing cutaneous patches, plaques, nodules, or generalized redness

A

Mycosis fungoides/Sezary syndrome

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19
Q

Adult, lymphocytosis, splenomegaly, neutropenia and anemia, maybe autoimmune (rheumatologic) disease

A

Large granular lymphocytic leukemia

20
Q

Small monoclonal Ig spike

A

CLL/SLL

21
Q

Hypogammaglobulinemia, multiple bacterial infections

A

CLL/SLL

22
Q

10% to 15% of CLL/SLL patients may develop ___ or ___ due to autoantibodies

A

Hemolytic anemia or thrombocytopenia

23
Q

HIV+, EBV+ neoplastic B cells, rapidly growing mass(es)

A

Immunodeficiency-associated large B-cell lymphoma (DLBCL subtype)

24
Q

HIV+, KSHV/HHV-8, malignant pleural or ascitic effusion, cells w/ clonal IgH rearrangements, no B or T cell surface markers

A

Primary effusion lymphoma (DLBCL subtype)

25
Q

Children/young male, mass in ileocecum or peritoneum

A

Sporadic (American) Burkitt Lymphoma

26
Q

Older adult, asymptomatic, moderately large monoclonal Ig population in the blood (but less than 3 gm/dL)

A

Monoclonal gammopathy of undetermined significance (MGUS)

27
Q

Asymptomatic, monoclonal Ig population in blood greater than 3 gm/dL, plasma cells are 10% to 30% of marrow cellularity

A

Smoldering myeloma (between MGUS and MM)

28
Q

50s or 60s, many plasma cells in bone marrow, monoclonal IgM in blood, hyperviscosity

A

Lymphoplasmacytic lymphoma

29
Q

Nonspecific symptoms, lymphadenopathy, hepatosplenomegaly, anemia, maybe autoimmune hemolysis via cold agglutinins

A

Lymphoplasmacytic lymphoma

30
Q

Visual impairment, neurologic problems, bleeding, symptoms in cold temperatures

A

Hyperviscosity syndrome - due to excess IgM secretion

31
Q

Salivary gland disease or thyroid gland disease or chronic gastritis

A

Marginal zone lymphoma - MALToma type

32
Q

Rheumatoid arthritis, splenomegaly, neutropenia

A

Felty syndrome - due to Large granular lymphocytic leukemia

33
Q

Young adult male or older male, painless lymphadenopathy, cutaneous anergy, systemic symptoms, advanced tumor stage

A

Mixed-Cellularity HL

34
Q

Young adult, mediastinal mass, early tumor stage, lacunar cells

A

Nodular sclerosis HL

35
Q

Older adult or HIV+ or poor country, systemic symptoms, late tumor stage, poor prognosis

A

Lymphocyte depletion HL

36
Q

Young male, cervical or axillary lymphadenopathy, excellent prognosis

A

Lymphocyte predominance HL

37
Q

Older adult, anemia, thrombocytopenia, neutropenia, much hemorrhaging, fever, fatigue, recurrent opportunistic infections (Pseudomonas, fungi, commensals)

A

AML

38
Q

Older adult, maybe asymptomatic, maybe weakness, infections, hemorrhages

A

MDS

39
Q

Middle age, slow onset, anemia and thrombocytopenia symptoms, dragging sensation in abdomen or LUQ pain, later myeloid blasts in the blood and marrow

A

CML

40
Q

Late middle age adult, slow onset, plethora, cyanosis, headache, dizziness, HTN, GI symptoms, intense pruritis, peptic ulceration, hyperuricemia

Major risk for what?

A

Polycythemia vera

DVT, stroke, MI, bowel infarction, or minor hemorrhages

41
Q

Older adult, elevated platelet count, thrombosis (DVT, venous thromboses, MI), hemorrhage

A

Essential thrombocytopenia

42
Q

Throbbing and burning of hands and feet

A

Erythromelalgia - due to small arteriole occlusion in PCV or ET

43
Q

Older adult, progressive anemia and splenomegaly, fullness in LUQ, nonspecific symptoms

A

Primary myelofibrosis - ealry

44
Q

Under 2 yo, cutaneous lesions over front and back of trunk and scalp, hepatosplenomegaly, lymphadenopathy, pulmonary lesions, bone lesions

A

Multifocal multisystem Langerhans cell histiocytosis (L-S disease)

45
Q

Child or older adult, eosinophilic infiltration of skull, ribs, or femur that may extend into soft tissue, diabetes insipidus

A

Histiocytosis X (Eosinophilic granuloma Langerhans cell histiocytosis)

46
Q

Skull bone defects, diabetes insipidus, eyeball protrusion

A

Hand-Schuller-Christian triad – Eosinophilic granuloma

47
Q

Adult, smoker, pulmonary lesion of macrophages

A

Pulmonary Langerhans cell histiocytosis

Heme/Lymph 2 (16 decks)

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