Genetics - Ch. 13 Flashcards Preview

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Flashcards in Genetics - Ch. 13 Deck (40):
1

3 main genetic mutation types that cause WBC cancer

- Pro-growth arrested differentiation (MYC, RTK)
- Txn factor increased self-renewal (MLL, PML-RARA)
- Decreased apoptosis (BCL2)

2

NOTCH1

T-ALL or worse prognosis of CLL

3

t(12;21) RUNX1-ETV6

B-ALL

4

TdT

Pre-B and Pre-T lymphoblasts (ALL)

5

CD1-8

Exception?

T cells (CD5 is some B cells)

6

t(9;22) BCR-ABL

B-ALL, CML

7

Deletions of 13q, 11q, 17p

CLL/SLL

8

BTK activation via kinase cascade

CLL/SLL

9

CD19, CD20

B cells (Pre-B, mature B- NOT plasma cells)

10

t(14;18) BCL2 overexpression

- Follicular lymphoma
- DLBCL (from FL)

11

MLL2 histone methyltransferase mutation

Follicular lymphoma

12

BCL6 dysregulation

Diffuse large B-cell lymphoma

13

KSHV/HHV-8 infection

Primary effusion lymphoma (DLBCL subtype)

14

Translocation w/ chromosome 8 -- t(8;14) usually

Burkitt lymphoma (Chromosome 8 = MYC gene, Chromosome 14 = Ig locus)

15

High cyclin D1, CD19, CD20, IgM and IgD w/ light chains, CD5+, CD23-

Mantle cell lymphoma

16

Monoclonal IgM secretion, MYD88 mutation, CD20+

Lymphoplasmacytic lymphoma

17

MALT1 or BCL10 fusion genes

Extranodal marginal zone lymphoma - secondary mutations that render the disease antigen-independent

18

t(11;18)

Extranodal marginal zone lymphoma

19

BRAF activation mutations

Hairy cell leukemia

20

t(11;14) cyclin-D1 - IgH fusion gene

Mantle cell lymphoma

21

Diverse rearrangements involving IgH

Multiple myeloma

22

Trisomy 12q

CLL/SLL

23

HTLV-1

Adult T-cell leukemia/lymphoma

24

ALK rearrangements

Anaplastic large-cell lymphoma

25

STAT3 point mutations

Large granular lymphocytic leukemia

26

CD45

Leukocyte common antigen (all leukocytes)

27

CD30

Activated B cells, T cells, monocytes, RS cells

28

CD34

Pluripotent hematopoietic stem cells and early progenitors

29

CD23, CD5, CD19, CD20

CLL/SLL

30

IgM, CD19, CD20, CD10, BCL6

Germinal center B cell

31

How to tell Burkitt lymphoma from other germinal center B cell neoplasms?

Burkitt = NO BCL2 expression

32

CD11c, CD25, CD103, annexin A1

Hairy cell leukemia

33

PAX5, CD15, CD30

Nodular sclerosis HL

34

CD20, BCL6, multilobed nucleus like popcorn kernel

L&H RS cell variant - Lymphocyte predominance HL

35

JAK2 tyrosine kinase mutations

PCV, ET, or PM

36

CD5+, B cells

- Mantle cell lymphoma
- CLL/SLL

37

Hyperdiploidy, hypodiploidy

B cell neoplasms

38

Monosomy 5, 7

MDS, AML via MDS

39

Deletions 5q, 7q, 20q

MDS, AML via MDS

40

Trisomy 8

MDS