Genital Development: Summary (LEC35) Flashcards Preview

Structures: Part Deux > Genital Development: Summary (LEC35) > Flashcards

Flashcards in Genital Development: Summary (LEC35) Deck (15)
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0
Q

where do primordial germ cells go

A

migrate from wall of yolk sac > developing gonads

1
Q

when is indifferent stage of development

A

til 7 weeks

2
Q

when are external genitalia distinguishable

A

after 12 weeks

3
Q

what determines gonadal sex?

A

TDF on y-chromosome

4
Q

what is necessary for mesonephric ducts to develop

A

leydig cells, > testosterone

5
Q

what inhibits development of paramesonephric ducts

A

Sertoli cells > MIS

6
Q

what stimulates normal ovarian development

A

no Y and 2 XX’s

7
Q

what becomes uterus and tubes?

A

paramesonephric ducts

8
Q

what does vagina form from

A

vaginal plate, from urogenital sinus

9
Q

what do indifferent external genitalia become

A

clitoris, labia

10
Q

what are male/female DSDs caused by, examples?

A

male- inadequate androgens or tissue insensitivity

female- CAH causing excess androgens

11
Q

why do most female genital tract anomalies occur

A

incomplete fusion of paramesonephric ducts

12
Q

what does abnormal testicular descent result in

A

cryptorchidism, ectopic testes

13
Q

what does persistence of processus vaginalis result in

A

congenital inguinal hernia, hydrocele

14
Q

what causes hypospadias

A

failure of fusion of urogenital folds