Genital Development: Summary (LEC35) Flashcards Preview

Structures: Part Deux > Genital Development: Summary (LEC35) > Flashcards

Flashcards in Genital Development: Summary (LEC35) Deck (15):
0

when is indifferent stage of development

til 7 weeks

1

where do primordial germ cells go

migrate from wall of yolk sac > developing gonads

2

when are external genitalia distinguishable

after 12 weeks

3

what determines gonadal sex?

TDF on y-chromosome

4

what is necessary for mesonephric ducts to develop

leydig cells, > testosterone

5

what inhibits development of paramesonephric ducts

Sertoli cells > MIS

6

what stimulates normal ovarian development

no Y and 2 XX's

7

what becomes uterus and tubes?

paramesonephric ducts

8

what does vagina form from

vaginal plate, from urogenital sinus

9

what do indifferent external genitalia become

clitoris, labia

10

what are male/female DSDs caused by, examples?

male- inadequate androgens or tissue insensitivity
female- CAH causing excess androgens

11

why do most female genital tract anomalies occur

incomplete fusion of paramesonephric ducts

12

what does abnormal testicular descent result in

cryptorchidism, ectopic testes

13

what does persistence of processus vaginalis result in

congenital inguinal hernia, hydrocele

14

what causes hypospadias

failure of fusion of urogenital folds