Flashcards in GI14 Deck (14):
What are the Malabsorption syndromes? What do they cause?
Diarrhea, Steatorrhea, weight loss, weakness, and vitamin and mineral deficiencies
"These Will Cause Devastating Absorption Problems"
-Responds to Antibiotics
-Affects ENTIRE small bowel (otherwise similar to celiac sprue)
-Infection with Tropheryma whipplei (gram POSITIVE)
-PAS-positive foamy macrophages in intestinal lamia propria, mesenteric nodes
What are associated symptoms with Whipple's disease?
-AutoAb to gluten (gliadin) in wheat
-Distal duodenum or Proximal Jejunum
-Loss of VILLI
-Most common is Lactase deficiency
-Normal appearing villi
-Decreased synthesis of apolipoprotein B
-Inability to make CHYLOMICRONS
-Cant secrete Cholesterol, or VLDL into bloodstream
-Fat accumulates in enterocytes
When and how does Abetalipoproteinemia present?
Malabsorption & Neurologic conditions
What pathologies can cause Pancreatic insufficiency?
What does Pancreatic insufficiency cause?
Malabsorption of fat and fat-soluble vitamins (ADEK)
*Increased neutral fat in stool
What HLA genes are associated with Celiac sprue?
*northern European descent
What autoimmune Abs are seen in Celiac sprue?
What are the histological findings in Celiac sprue?
-Blunting of villi
-Lymphocytes in lamina propria