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Flashcards in GI14 Deck (14):
1

What are the Malabsorption syndromes? What do they cause?

Diarrhea, Steatorrhea, weight loss, weakness, and vitamin and mineral deficiencies

"These Will Cause Devastating Absorption Problems"

Tropical sprue
Whipple's disease
Celiac sprue
Disaccharidase deficiency
Abetalipoproteinemia
Pancreatic insufficiency

2

Tropical sprue.

-Unknown cause
-Responds to Antibiotics
-Affects ENTIRE small bowel (otherwise similar to celiac sprue)

3

Whipple's disease.

-Infection with Tropheryma whipplei (gram POSITIVE)
-PAS-positive foamy macrophages in intestinal lamia propria, mesenteric nodes
-Older men

4

What are associated symptoms with Whipple's disease?

Cardiac symptoms
Arthralgias
Neurologic symptoms

5

Celiac sprue.

-AutoAb to gluten (gliadin) in wheat
-Distal duodenum or Proximal Jejunum
-Loss of VILLI

6

Disaccharidase deficiency.

-Most common is Lactase deficiency
-Normal appearing villi
-Osmotic diarrhea

7

Abetalipoproteinemia.

-Decreased synthesis of apolipoprotein B
-Inability to make CHYLOMICRONS
-Cant secrete Cholesterol, or VLDL into bloodstream
-Fat accumulates in enterocytes

8

When and how does Abetalipoproteinemia present?

Early Childhood
Malabsorption & Neurologic conditions

9

What pathologies can cause Pancreatic insufficiency?

-Cystic fibrosis
-Obstructing cancer
-Chronic pancreatitis

10

What does Pancreatic insufficiency cause?

Malabsorption of fat and fat-soluble vitamins (ADEK)

*Increased neutral fat in stool

11

What HLA genes are associated with Celiac sprue?

HLA-DQ2
HLA-DQ8

*northern European descent

12

What autoimmune Abs are seen in Celiac sprue?

Anti-gliadin
Anti-endomysial
Anti-tissue transglutaminase

13

What are the histological findings in Celiac sprue?

-Blunting of villi
-Lymphocytes in lamina propria

14

What other condition is Celiac sprue associated with?

Dermatitis herpetiformis