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Flashcards in GI20 Deck (12):
1

Diagnostic Use:
- Aminotransferases (AST & ALT) (2)
"liver enzymes"

Viral Hepatitis (ALT > AST)

Alcoholic Hepatitis (AST > ALT)

2

Diagnostic Use:
- Alkaline phosphatase (ALP) - (3)

-Obstructive liver disease (hepatocellular carcinoma)
-Bone disease
-Bile duct disease

3

Diagnostic Use:
- y-glutamyl transpeptidase (GGT)

-Increased in various liver and biliary diseases like ALP

*NOT in bone disease

4

Diagnostic Use:
- Amylase (2)

-Acute pancreatitis
-Mumps

5

Diagnostic Use:
- Lipase (1)

-Acute pancreatitis

6

Diagnostic Use:
- Ceruloplasmin (1)

-Wilson's disease (DEcreased)

7

Reye's syndrome: Findings

-Mitochondrial abnormalities
-Fatty liver (microvascular fatty change)
-Hypoglycemia
-Vomiting
-Hepatosplenomegaly
-Coma

8

Reye's syndrome: Associations

Viral infection (especially VZV & influenza B)
-Treated with Aspirin

9

Reye's syndrome: Mechanism

-Aspirin metabolites DEcrease B-oxidation by reversible inhibtion of mitochondrial enzyme

*Avoid aspirin in children, EXCEPT Kawasaki's disease

10

Alcoholic Liver Disease:
- Hepatic steatosis

-Short-term change with moderal alcohol intake
-Microvesicular fatty change that may be REVERSIBLE with alcohol cessation

11

Alcoholic Liver Disease:
- Alcoholic hepatitis

-Sustained, long-term consumption
-Swollen and necrotic hepatocytes w/ neutrophilic infiltration
-Mallory bodies are present
-AST > ALT (ratio >1.5)

"make a toAST with alcohol"

12

Alcoholic Liver Disease:
- Alcoholic cirrhosis

-Final, irreversible form
-Micronodular, irregularly shrunken liver
-"Hobnail" appearance
-Sclerosis around Central vein (zone III)