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Flashcards in GI10 Deck (18):
1

What products are secreted by Parietal cells?

Intrinsic Factor
Gastric Acid

2

What is the function of Intrinsic Factor?

Vitamin B12 binding protein
*Required for B12 uptake in Terminal Ileum

3

What stimulates parietal cells to secrete Gastric Acid?

Histamine
ACh
Gastrin

4

What inhibits parietal cell secretion of Gastric Acid?

Somatostatin
GIP
Prostaglandin
Secretin

5

What is the function of Gastric Acid?

Decrease stomach pH

6

What is secreted from Chief cells?

Pepsin (Pepsinogen-Inactive form)

7

What is the function of Pepsin?

Protein digestion

8

What stimulates Pepsin release from Chief cells?

Vagal stimulation
Local Acid

9

How is Pepsinogen (inactive) converted to Pepsin (active)?

H+

10

What is the source of HCO3- in the GI tract?

Mucosal cells
Brunner's glands

11

Where are mucousal cells located?

Stomach
Duodenum
Salivary glands
Pancreas

12

Where are Brunner's glands located?

Duodenum

13

What stimulates HCO3- secretion?

Pancreatic & Biliary secretion with Secretin

14

What are the products found in saliva?

Amylase
HCO3-
Mucins

15

What is the function of Amylase?

Digest Starch

16

What is the function of HCO3- in saliva?

Neutralizes Bacterial Acids

17

What is the function of Mucins in saliva?

Lubricate food

18

What condition do you see Hypertrophy of Brunner's glands?

Peptic Ulcer disease