GI23 Flashcards Preview

FA - GastroIntestinal > GI23 > Flashcards

Flashcards in GI23 Deck (13):
1

Types of Biliary Tract Diseases.

Primary biliary cirrhosis
Secondary biliary cirrhosis
Primary sclerosing cholangitis

2

Secondary biliary cirrhosis:
- Pathophysiology

-Extrahepatic biliary obstruction
-Increased pressure in intrahepatic ducts
-Injury/fibrosis and bile stasis

3

Primary biliary cirrhosis:
- Pathophysiology

-Autoimmune reaction
-Lymphocytic infiltrate + granulomas

4

Primary sclerosing cholangitis:
- Pathophysiology

-Unknown cause
-Concentric "onion skin" bile duct Fibrosis
-Alternating strictures and dilation with "beading" of intra- and extrahepatic bile ducts on ERCP

5

Causes of Extrahepatic biliary obstruction.

-Gallstone
-Biliary stricture
-Chronic pancreatitis
-Carcinoma of the pancreatic head

6

All Biliary tract diseases: Presentation

-Pruritis
-Jaundice
-Dark urine
-Light stools
-Hepatosplenomegaly

7

All Biliary tract diseases: Labs

INcreased:
-Conjugated bilirubin
-Cholesterol
-Alkaline phosphatase

8

Increased serum mitochondrial antibodies.

Primary biliary cirrhosis

9

Complicated by ascending cholangitis.

Secondary biliary cirrhosis

10

Hypergammaglobulinemia (IgM).

Primary sclerosing cholangitis

11

Can lead to 2˚ biliary cirrhosis.

Primary sclerosing cholangitis

12

Associated with autoimmune conditions (e.g., CREST, RA, celiac disease)

Primary biliary cirrhosis

13

"Beading" of intra- and extrahepatic bile ducts on ERCP.

Primary sclerosing cholangitis