Hematology -- cancer translocations and cell markers

Question 1

Reed Sternber cells

Answer 1

CD15 and CD30 (B-cell origin)

Question 2

8,14

Answer 2

Burkitt lymphoma (non hodgkins)

Ig (14), Myc (8)

Myc is a transcripton factor

Question 3

9, 22

Answer 3

Philadelphia chromosome - CML - chronic myleoid leukemia ( non-hodgkins)

Brc (22), Abl (9)

Question 4

14, 18

Answer 4

Follicular lymphoma ( non- hodgkins)

Ig (14), BCL-2 (18)
BCL-2 blocks apoptosis

** Waxing and Waning** lymphadenopathy

Question 5

11, 14

Answer 5

Mantle cell lymphoma ( non- hodgkins)

cyclin D1 (11) Ig (14)

Question 6

15, 17

Answer 6

M3 type of AML

- responds to all- trans retinoic acid

Question 7

8,21

Answer 7

AML seen in patients with down syndrome

Question 8

Markers of T cells

Answer 8

TCR ( binds antigent-MHC complex)
CD3 (associated with TCR for signal)
CD28 (binds B7 on APC)

Question 9

T helper cell cell markers

Answer 9

CD4, CD40L

Question 10

Cytotoxic T cell markers

Answer 10

CD8

Question 11

Regulatory T cell markers

Answer 11

CD4

CD25

Question 12

B cell markers

Answer 12

Ig (binds antigen) -- IgM and IgD are 1st.
CD19, CD20, CD21 (receptor for EBV)
CD40 (binds to T-helper cell)
MHC II
B7 (helps activate B cells)

Question 13

Macrophage cell markers

Answer 13

CD14 **
CD40
MHC II
B7

Question 14

Natural Killer cell markers

Answer 14

CD 16** (binds Fc of IgG)
- antibody dependent cell mediated cytotoxicity
CD56 ** unique marker for NK

Question 15

Hematopoietic stem cell marker

Answer 15

CD34