Neurotransmitter changes seen with disease FA 507 Flashcards Preview

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Flashcards in Neurotransmitter changes seen with disease FA 507 Deck (11)
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1

Alzheimers

Decrease ACh
Increase glutamate

2

Anxiety

Increase NE
Decreased GABA and 5-HT

3

Depression

Decreased NE
Decreased Dopamine and 5-HT

4

Huntington Disease

Increased Dopamine
Decreased ACh, GABA

5

Parkinson disease

Increased ACh
Decreased Dopamine

6

Schizophrenia

Increased dopamine

7

Location of synthesis of NE?

Locus ceruleus (pons), reitcular formation, solitary tract

8

Location of Dopamine synthesis?

Ventral tegmentum and substansia nigra pars compacta (midbrain)

9

Location of 5-HT synthesis?

Raphe nuclei (pons, medulla, midbrain)

10

Location of ACh synthesis?

Basal nucleus of Meyner

* degradation of this area in Alzheimer's

11

Location of GABA synthesis

Nucleus accumbens (recall this is in the the reward center, pleasures, addition and fear.