Rate-determining enzymes of metabolic processes Flashcards Preview

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Flashcards in Rate-determining enzymes of metabolic processes Deck (13)
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1

Glycolysis?

Phosphofructokinase 1

(+) AMP, Fructose 2,6 bisphosphate
(-) ATP, Citrate

2

Guconeogenesis

Fructose 1,6 bisphosphatase

(+) ATP, acetyl-coA
(-) AMP, fructose 2,6 bisphosphate

3

TCA cycle

Isocitrate dehydrogenase

(+) ADP
(-) ATP, NADH

4

Glycogenesis

Glycogen synthase

(+) Glucose 6 phosphate, insulin, cortisol
(-) epinephrine, glucagon

5

Glycogenolysis

Glycogen phosphorylase

(+) Epinephrin, Glucagon, AMP
(-) Glucose 6 phosphate, insulin, ATP

6

HMP shunt

Glucose-6-phosphate dehydrogenase (G6PD)

(+) NADP+
(-) NADPH

7

De novo pyrimidine synthesis

Carbamoyl phosphate synthetase II (cytoplasm)

(+) ATP
(-) UTP

8

De novo purine synthesis

Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase

(-) AMP, inosine monophosphate, GMP

9

Urea Cycle

Carbamoyl phosphate synthetase I (mitochondria)

(+) N-acetylglutamate

10

Fatty acid synthesis

Acetyl CoA carboxylase (ACC)

(+) insulin, citrate
(-) glucagon, palmitoyl-coA

11

Ketogenesis

HMG-coA synthase

12

Cholesterol synthesis

HMG-coA reductase

(+) insulin, thyroxine
(-) Glucagon, cholesterol

13

Heme synthesis

(not metabolism related but still important)

Aminolevulinic acid synthase