Flashcards in Drugs that interfere with electron transport chain Deck (14)
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1
Who are the electron transport inhibitors?
Rotenone
cyanide
antimycin A
CO
2
Who are the ATP synthase inhibitors
Oligomycin
3
Who are the uncoupling agents
2,4 Dinitrophenol (2,4 DNP)
Aspirin
Thermogenin (brown fat)
4
what is the mechanism of the electron transport inhibitors?
directly inhibit electron transport causing a decrease in proton gradient and blocking ATP synthesis
5
What is the mechanism of the ATP synthase inhibitors
Directly inhibit mitochondrial ATP synthase, causing an increase proton gradient. No ATP is produced because electron transport stops.
6
What is the mechanism behind uncoupling agents
increase permeability of the membrane causing a decrease in the proton gradient and increase in O2 consumption.
ATP synthesis stops
Electron transport continues
Produces HEAT
7
Where does Rotenone inhibit?
Complex 1 : NADH reductase
rotenone is an insecticide/ fish poison
8
Amytal?
Complex 1: NADH reductase
9
MMP?
Complex 1: NADH reductase
Recall that it can cause Parkinsonism like features
10
Antimycin A blocks who?
Complex III: Cytochrome b+ c1
11
Cyanide (CN-) blocks?
Complex 4: Cytochrome a+ a3
12
CO blocks who in the electron transport chain?
Complex 4: Cytochrome a+ a3
13
H2S and N3- block who in the electron transport chain
Complex 4: Cytochrome a+ a3
14