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Low Yield Semmelweis > Hematology - Histological Slides > Flashcards

Hematology - Histological Slides Flashcards

1
Q

Myeloid Lineage

Cell Types 1 to 3 should be seen in the ____ ______ only!

A

Myeloid Lineage

Cell Types 1 to 3 should be seen in the Bone Marrow only!

*These are Myeloblast, Promyelocyte and Myelocyte

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2
Q

Hematology - Important cells

What type of cell is Indicated by the number - 1 ?

A

Hematology - Important cells

1 - Monocyte

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3
Q

Erythrocyte Alterations

What type of Alteration is indicated by the arrow?

What could be the cause?

A

Erythrocyte Alterations

Sickle cell - Molecular aggregation of Hgb‐S

Etiology -

  • SS; SC; S‐thal; rarely S‐trait

* There is also a Nucleated RBC unrelated to the question

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4
Q

Erythroid Lineage

What type of cell is Indicated by the number - 2 ?

A

Erythroid Lineage

2 = Basophillic Erythroblast

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5
Q

Atypical Lymphocytes - Smudge Cells

In what pathological conditions can we see these?

A

Atypical Lymphocytes - Smudge Cells

Chronic Lymphocytic Leukemia - CLL

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6
Q

Erythroid Lineage

What type of cell is Indicated by the number - 5 ?

A

Erythroid Lineage

5 = Reticulocyte

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7
Q

Atypical Lymphocytes - Downey Cells

In what pathological conditions can we see these?

A

Atypical Lymphocytes - Downey Cells

Infectious Mononucleosis - EBV Infection

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8
Q

Erythroid Lineage

What type of cell is Indicated by the number - 1 ?

A

Erythroid Lineage

1 = Proerythroblast

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9
Q

Erythroid Lineage

Cell types 1 to 4 should be seen only in the ____ ______!

A

Erythroid Lineage

Cell types 1 to 4 should be seen only in the Bone Marrow!

**Proerythroblast, Basophillic Erythroblast, Polychromatic Erythroblast and Orthochromatic Eryhtroblast!

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10
Q

Hematology - Important cells

What type of cell is Indicated by the number - 4 ?

A

Hematology - Important cells

4 - Megakaryocyte

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11
Q

Hematology - Important cells

What type of cell is Indicated by the number - 8 ?

A

Hematology - Important cells

8 - Plasma cells

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12
Q

Myeloid Lineage

What type of cell is Indicated by the number - 3 ?

A

Myeloid Lineage

3 = Myelocyte

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13
Q

Döhle bodies

In what pathological conditions can we see these?

*aid in ddx?

A

Döhle bodies

  • an abnormal basophilic structure in the cytoplasm
  • Seen in Leukemoid reaction helps in ddx from CML
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14
Q

Erythrocyte Alterations

What type of Alteration is indicated by the arrow?

What could be the cause?

A

Erythrocyte Alterations

Elliptocytes/ovalocytes -Abnormal cytoskeletal proteins

Etiology -

  • Megaloblastic anemia
  • Hereditary elliptocytosis
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15
Q

Hematology - Important cells

What type of cell is Indicated by the number - 9 ?

A

Hematology - Important cells

9 - Mast cell

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16
Q

Myeloid Lineage

What type of cell is Indicated by the number - 6 ?

A

Myeloid Lineage

6 = Segmented cell

*Neutrophill in this case

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17
Q

Microcytic Hypochromic Anemia ‐ IDA

What are the alterations possible here?

A

Microcytic Hypochromic Anemia ‐ IDA

  • Anisocytosis
  • Poikilocytosis
  • Anulocytosis
  • Target cells
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18
Q

Hematology - Important cells

What type of cell is Indicated by the number - 2 ?

A

Hematology - Important cells

2 - Lymphocyte

19
Q

Erythrocyte Alterations

What type of Alteration is indicated by the arrow?

What could be the cause?

A

Erythrocyte Alterations

Tear drop cells - Distorted, drop shaped RBCs

Etiology -

  • Smear artifact
  • Myelofibrosis
  • space occupying processes of the bone marrow (e.g. metastases)
20
Q

Myeloid Lineage

What type of cell is Indicated by the number - 2 ?

A

Myeloid Lineage

2 = Promyelocyte

21
Q

Erythrocyte Alterations

What type of Alteration is indicated by the arrow?

What could be the cause?

A

Erythrocyte Alterations

Stomatocyte - Mouth-like Membrane defect

Etiology -

  • Smear artifact
  • Hereditary stomatocytosis
22
Q

Myeloid Lineage

What type of cell is Indicated by the number - 4 ?

A

Myeloid Lineage

4 = Metamyelocyte

23
Q

Erythrocyte Alterations

What type of Alteration is indicated by the arrow?

What could be the cause?

A

Erythrocyte Alterations

Target cells - Hemoglobinopathies

Etiology -

  • Thalassemia
  • Obstructive liver disease
  • Iron deficiency anemia
24
Q

Erythrocyte Alterations

What type of Alteration is indicated by the arrow?

What could be the cause?

A

Erythrocyte Alterations

Schistocytes (helmet cells)- Fragmented RBCs

Etiology -

  • DIC; TTP; HUS
  • Vasculitis
  • Prosthetic heart valve
  • Severe burns
25
**_Auer Rod_** In what Pahtological conditions this phenomena happens?
**_Auer Rod_** * **_Myeloid Leukemias:_** AML, acute promyelocytic leukemia, and high-grade MDS and MPN. \* There are other Myeloid leukemias like CML that dont present this
26
**_Erythrocyte Alterations_** What type of Alteration is indicated by the arrow? What could be the cause?
**_Erythrocyte Alterations_** **Echinocytes (Burr cells) - Altered lipid in cell membrane** Etiology - * Uremia * Piruvate‐kinase deficiency * Aged transfused RBC
27
**_Erythrocyte Alterations_** What type of Alteration is indicated by the arrow? What could be the cause?
**_Erythrocyte Alterations_** **Howell Jolly body (Nuclear remnant)** Etiology - * Megaloblastos anaemia * Splenectomy or spleen hypofunction * Sever hemolytic anemia * Herediter spherocytosis
28
**_Hematology - Important cells_** What type of cell is Indicated by the number - **_3_** ?
**_Hematology - Important cells_** **_3 - Foam cell_**
29
**_Hematology - Important cells_** What type of cell is Indicated by the number - **_5_** ?
**_Hematology - Important cells_** **_5 - Adipocyte (Yellow Marrow)_**
30
What type of cell is circled in red?
Proerythroblast
31
**_Myeloid Lineage_** What type of cell is Indicated by the number - **_1_** ?
**_Myeloid Lineage_** ## Footnote **1 = Myeloblast**
32
**_Erythroid Lineage_** What type of cell is Indicated by the number - **_3_** ?
**_Erythroid Lineage_** ## Footnote **3 = Polychromatic Erythroblast**
33
**_Erythrocyte Alterations_** What type of Alteration is indicated by the arrow? What could be the cause?
**_Erythrocyte Alterations_** **Spherocyte** (Absent central pallor - Looks smaller) Etiology - * Hereditary spherocytosis * Immune hemolytic anemia
34
**_Erythroid Lineage_** What type of cell is Indicated by the number - **_4_** ?
**_Erythroid Lineage_** ## Footnote **4 = Orthochromatic Erythroblast**
35
**_Erythrocyte Alterations_** What type of Alteration is indicated by the arrow? What could be the cause?
**_Erythrocyte Alterations_** **Malaria - Plasmodium vivax**
36
**_Erythroid Lineage_** What type of cell is Indicated by the number - **_6_** ?
**_Erythroid Lineage_** ## Footnote **6 = Erythrocyte**
37
**_Erythrocyte Alterations_** What type of Alteration is indicated by the arrow? What could be the cause?
**_Erythrocyte Alterations_** **Basophilic stippling (Precipitated RNA)** Etiology - * Lead or heavy metal poisoning * MDS * Sideroblastic anemia
38
**_Myeloid Lineage_** What type of cell is Indicated by the number - **_5_** ?
**_Myeloid Lineage_** ## Footnote **5 = Band cell**
39
**_Megaloblastic Anemia_** What are the alterations possible here?
**_Megaloblastic Anemia_** * Macro‐ovalocytic * Polychromasia * Hypersegmented neutrophils * Howell‐Jolly bodies
40
**_Hematology - Important cells_** What type of cell is Indicated by the number - **_7_** ?
**_Hematology - Important cells_** **_7 - Osteoclast_**
41
**_Myeloid Lineage_** Cell Types 4 to 6 can be seen in the ____ \_\_\_\_\_\_ and \_\_\_\_\_\_\_\_!
**_Myeloid Lineage_** Cell Types 4 to 6 can be seen in the **_Bone Marrow_** and **_Periphery_**! \*These are Metamyelocyte, Band and Segmented cells
42
**_Erythroid Lineage_** Cell types 5 and 6 can be seen in the ____ \_\_\_\_\_\_ and \_\_\_\_\_\_\_\_!
**_Erythroid Lineage_** Cell types 5 and 6 can be seen in the **_Bone Marrow_** and **_Periphery_**! \*\*Reticulocytes and RBCs
43
**_Hematology - Important cells_** What type of cell is Indicated by the number - **_6_** ?
**_Hematology - Important cells_** **_6 - Osteoblast_** (the left 6 indicates large lymphocytes)
44
What type of cell is circled in red?
Band cell

Low Yield Semmelweis (37 decks)

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