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Flashcards in Hematopoiesis Deck (25):
1

serum

plasma w/o clotting factor

2

hematocrit

volume of plasma/volume of RBC

3

HSC are typically in this phase

Gq; at any time only a few are actually giving rise to peripheral blood cells

4

glycoprotein marker on HSC

CD34

5

myeloid precursor cell gives rise to

platelets
monos
PMNs
RBCs

6

lymphoid stem cells give rise to

NK lymphocytes
T lymphocytes
B lymphocytes

7

where are stem cells developed

yolk sac--> @ 6 weeks liver/spleen--> @ 6/7 monthsbone marrow

8

in adulthood, hematopoietic marrow confined to

axial skeleton and proximal ends of femurs

9

in times of need what areas help out

fat in stem cell areas, liver, and spleen

10

IL3

needed to go from stem cell to lymphoid OR myeloid stem cell

11

SCF

this and IL3 needed to go from stem cell to myeloid precursor cell

12

IL2

lympoid stem cell-->b lymp, t lymph, or NK cells

13

just GM-CSF

myeloid precursor cell-->monos

14

G-CSF & GM-CSF

myeloid precursor-->PMNs

15

MCHC

average concentration of hemoglobin in a given volume of RBC

16

MCV

average volume of RBCj

17

RDW

coefficient of variation
increase in RDW= large variation in size

18

causes of eosinophilia

Neoplasm
Asthma
Allergic processes
Collagen vascular diseases
Parasites

19

bad thing about ILE

stimulates prolfiieration of AML blasts

20

bad thing about G-CSF

stimulates proliferation and differentiation of WEHI3B myelomonocytic leukemia

increases prolferation of small cell carcinoma and colon carcinoma cell lines, L-60, and KG1

21

other things G-CSF does

increases PMN phagocytossi and releases PMNs from bone marrow

22

good things of GM-CSF

enhances cytotoxic and phagocytic actvty of PMNs, stimulates erythropoeisis in the presence of erythropoietin

23

bad things GM-CSF

stmulates AML blasts to proliferate
prolfieration of small cell and colon carcinoma

24

IL2 is a

growth factor for t cells

25

IL1

actvates restng t cells
cofactor for t cell ad b cell prolfieration
induces producton of other growth factors
stmulates early myeloid cells