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Flashcards in Lymphopoiesis Deck (45):
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symptoms of lymphoma

local enlargement; typically non-tender
compression of adjacent structures
release of cytokines, producing sytsemic B symptoms

1

light cahins can establish

clontality in b cells

2

b cell lymphoma of follicular origin

monoclonal light chain, CD 19, CD20, CD5 pos, CD 10 neg

3

b cell small lymphocytic lymphoma

monoclonal light chain, CD 19, CD20, CD5, CD 23 pos, CD 10 neg

4

indolent lymphmas

Follicular
Marginal Zone
MALT

5

intermediate lymphoma

diffuse large cell
peripheral t cell

6

highly aggressive lymphoma

burkitt

7

4 types of classical hodgkins lymphoma

nodular sclerosing
lymphocyte predominant
mixed cellularity
lymphocyte depleted

8

most cases of lyphoma are not

familial

9

fatigue is NOT

a b symptom

10

LDH is a sign of

cell turnover in NHL

11

Ann Arbor Staging System

Stage 1- single lymph node on one side of diaphragm
Stage 2- 2+ on same side of diaphragm
Stage 3- lymphs on both sides of diaphragm
Stage 4- diffuse involvement of extralymphatic sites

12

IPI

age >60
perf status (2-4- lower is better)
LDH level- elevated
extranodal involvement >1 site
stage (III-IV)

13

diffuse large cell lymphoma stage 1/2 cure

chemo and radiation

14

diffuse cell treatment stage III/IV

chemo only

15

CHOP

cyclophosphamide
doxorubicin
vincristine
prednisone

16

follicular lymphoma

slow dividing lymphocytes-->disease of slow accumulation due to defect apoptosis
increase in regulated BCL2-->anti-apoptic cells

17

grade 1 follicular lymphoma

small cleaved lymphocytes

18

treatment of follicular lymphoma

watch and wait
treat for symptoms!

19

1/2a focciluclar

radiation only

20

2B/3 follicular lymphoma

gentle chemo
CHOP w/o anthracyclin

21

incurable

unless autologous stem cell or localized disease

22

Marginal zone lymphomas

nodal marginal zone lymphoma
extramarginal zone lymphoma (MALT)
mantle cell lymphoma

23

nodal marginal zone lymphoma

very similar presentation and course to follicular so treat like follicular

24

extramarginal zone lymphoma

hpyloti; treat up to a year

25

mantle cell lymphoma

aggressive; noncurable
t(11;14)-->cyclin D-->pushes cell through cell cycle

26

Burkitt lymphoma

from germinal center- trans of MYC ongene-->persistnat expression-->constant replication

27

treatment sporadic bburkitt cell lymphoma

intense, short,multi-agent chemo

28

biggest progonostic factor if Hodgkins Lymphoma

PET scan negative after 2 treatments

29

hodgkins lymphoma

generalized adenopathy-->cervical/axillary
-above mediastinum
mediastinal mass
systemic symptoms
-B
-pruritis
-alcohol-induced pain
hepatosplenomegaly

30

nodular lymphocyte predom

neck; young pts
popcorn cell

31

classical hogdkins lymphoma

nodular sclerosis- most common
mixed cellularity- most aggressive- more RS, eosino, plasma, mono nuclear variant RS
lymphocyte rich
lymphocyte depleted- older patients, retroperitoneum, loss lympho, sclerosis, pleomorphic RS cell

32

cRABi

hypercalcemia
renal insufficiency
anemia
bone marrow lesions
infections

33

multiple myeloma where does cell come from

post germinal

34

cds for MM

cd38, cd138

35

IG with worse prognosis

iga

36

follicular markers

CD10
CD20
BCL2
t(14;18)

37

DLCL

CD20
BCL2
BCL6

38

Mantle cell

CD5
CD20
cyclin D1
t(11;14)

39

marginal markers

CD20
t(11;18)
c-myc

40

CLL/SLL markers

CD5
CD20
s/g dim CD23+

41

CML

t(9;22)

42

PV

Jak2

43

AML

t (18;21)
Inv 6
T(16;17)

44

poor prognosis AML

Del 5,7
complex CG