Lymphopoiesis

Question 0

light cahins can establish

Answer 0

clontality in b cells

Question 1

symptoms of lymphoma

Answer 1

local enlargement; typically non-tender
compression of adjacent structures
release of cytokines, producing sytsemic B symptoms

Question 2

b cell lymphoma of follicular origin

Answer 2

monoclonal light chain, CD 19, CD20, CD5 pos, CD 10 neg

Question 3

b cell small lymphocytic lymphoma

Answer 3

monoclonal light chain, CD 19, CD20, CD5, CD 23 pos, CD 10 neg

Question 4

indolent lymphmas

Answer 4

Follicular
Marginal Zone
MALT

Question 5

intermediate lymphoma

Answer 5

diffuse large cell

peripheral t cell

Question 6

highly aggressive lymphoma

Answer 6

burkitt

Question 7

4 types of classical hodgkins lymphoma

Answer 7

nodular sclerosing
lymphocyte predominant
mixed cellularity
lymphocyte depleted

Question 8

most cases of lyphoma are not

Answer 8

familial

Question 9

fatigue is NOT

Answer 9

a b symptom

Question 10

LDH is a sign of

Answer 10

cell turnover in NHL

Question 11

Ann Arbor Staging System

Answer 11

Stage 1- single lymph node on one side of diaphragm
Stage 2- 2+ on same side of diaphragm
Stage 3- lymphs on both sides of diaphragm
Stage 4- diffuse involvement of extralymphatic sites

Question 12

IPI

Answer 12

age >60
perf status (2-4- lower is better)
LDH level- elevated
extranodal involvement >1 site
stage (III-IV)

Question 13

diffuse large cell lymphoma stage 1/2 cure

Answer 13

chemo and radiation

Question 14

diffuse cell treatment stage III/IV

Answer 14

chemo only

Question 15

CHOP

Answer 15

cyclophosphamide
doxorubicin
vincristine
prednisone

Question 16

follicular lymphoma

Answer 16

slow dividing lymphocytes–>disease of slow accumulation due to defect apoptosis
increase in regulated BCL2–>anti-apoptic cells

Question 17

grade 1 follicular lymphoma

Answer 17

small cleaved lymphocytes

Question 18

treatment of follicular lymphoma

Answer 18

watch and wait

treat for symptoms!

Question 19

1/2a focciluclar

Answer 19

radiation only

Question 20

2B/3 follicular lymphoma

Answer 20

gentle chemo

CHOP w/o anthracyclin

Question 21

incurable

Answer 21

unless autologous stem cell or localized disease

Question 22

Marginal zone lymphomas

Answer 22

nodal marginal zone lymphoma
extramarginal zone lymphoma (MALT)
mantle cell lymphoma

Question 23

nodal marginal zone lymphoma

Answer 23

very similar presentation and course to follicular so treat like follicular

Question 24

extramarginal zone lymphoma

Answer 24

hpyloti; treat up to a year

Question 25

mantle cell lymphoma

Answer 25

aggressive; noncurable | t(11;14)-->cyclin D-->pushes cell through cell cycle

Question 26

Burkitt lymphoma

Answer 26

from germinal center- trans of MYC ongene-->persistnat expression-->constant replication

Question 27

treatment sporadic bburkitt cell lymphoma

Answer 27

intense, short,multi-agent chemo

Question 28

biggest progonostic factor if Hodgkins Lymphoma

Answer 28

PET scan negative after 2 treatments

Question 29

hodgkins lymphoma

Answer 29

``` generalized adenopathy-->cervical/axillary -above mediastinum mediastinal mass systemic symptoms -B -pruritis -alcohol-induced pain hepatosplenomegaly ```

Question 30

nodular lymphocyte predom

Answer 30

neck; young pts | popcorn cell

Question 31

classical hogdkins lymphoma

Answer 31

nodular sclerosis- most common mixed cellularity- most aggressive- more RS, eosino, plasma, mono nuclear variant RS lymphocyte rich lymphocyte depleted- older patients, retroperitoneum, loss lympho, sclerosis, pleomorphic RS cell

Question 32

cRABi

Answer 32

``` hypercalcemia renal insufficiency anemia bone marrow lesions infections ```

Question 33

multiple myeloma where does cell come from

Answer 33

post germinal

Question 34

cds for MM

Answer 34

cd38, cd138

Question 35

IG with worse prognosis

Answer 35

iga

Question 36

follicular markers

Answer 36

CD10 CD20 BCL2 t(14;18)

Question 37

DLCL

Answer 37

CD20 BCL2 BCL6

Question 38

Mantle cell

Answer 38

CD5 CD20 cyclin D1 t(11;14)

Question 39

marginal markers

Answer 39

CD20 t(11;18) c-myc

Question 40

CLL/SLL markers

Answer 40

CD5 CD20 s/g dim CD23+

Question 41

CML

Answer 41

t(9;22)

Question 42

PV

Answer 42

Jak2

Question 43

AML

Answer 43

t (18;21) Inv 6 T(16;17)

Question 44

poor prognosis AML

Answer 44

Del 5,7 | complex CG