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Flashcards in Intro to WBC Deck (18):
1

Absolute Neurtrophil Count

ANC= WBC x (%PMN + %bands)

2

leukocytosis

total WBC elevated above normal range

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band news

immature neutrophil

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patterns of leukocytosis/neutrophilia

shift neutrophila
left shift
leukemoid rxn
leukoerythroblastic rxn
leukemia

5

shift neutrophilia

demargination of marginal pool w/o proliferation
moderate in degree, rapid onset

6

shift neutrophilia generally seen with

steroids
epi injection
stress
seizures

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left shift

more bands and occasional metamyelocyte in periphery

8

leukemoid rxn

demargination and marrow proliferation
--increase in both mature and immature forms-->
involves a left shift

9

leukemoid rxn seen w/

infection, inflammation, metastatic cancer, G-CSF

10

leukoerythroblastic rxn

seen w/ damaged bone marrow causing premature release of precursors cells

11

you may see this cell in a leukoerythroblastic rxn

tear drop cells

12

neutropenia

an absolute PMN count below normal range 2200-7000 cells/ul

13

congenital causes of neutropenia

cyclic neutropenia (autosomal dominant)
severe congenital neutropenia (auto dom)
kostmann syndrome (auto recessve)

14

acquired causes of neutropenia

infection
drug/toxin
nutritional deficiencies
neoplasm
hypersplenism/splenomegaly
immune-induced

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ANC no significant risk for infection

1000-1500

16

ANC some increased risk, fever managed as outpatient

500-1000

17

ANC significantly increased risk of infection- cut off for antibiotics/hospitalization

<500

18

ANC severe risk fungal & opportunistic infection

ANC <200