Pharm Randoms Flashcards Preview

SBM > Pharm Randoms > Flashcards

Flashcards in Pharm Randoms Deck (65):
1

first line of care for diabetics with HTN

ace inhibitor

2

4 times of sympatholytic agents

act within CNS
act on autonomic ganglia
act on post-ganglionic neurons
block peripheral adrenergic receptors

3

what can clonidine help with

withdrawal symptoms of opioids

4

trimethaphan will

almost never be used, maybe just by anesthesiologist when patient is knocked out

only given by IV

5

1st drug approved for early BP lowering

reserpine

6

B-blockers will not

reduce chance of having a stroke, but a pt with HRN and a fib- 1st line because two birds one stone

7

labetolol is typically

not a first line drug due to so many side effects

8

ace inhibitors help with

angioedema

9

no B2 blockers for

asthma

10

angina

propanolol

11

goal BP reduction

25%

12

best anti HTN drug for pregnancy

clonidine/methyldopa

**treat to avoid pre-eclampsia

13

ACE inhibitors delay

development of renal failure

14

positive chronotropic agent

increases HR via SA

15

positive dromotropic agent

increase conduction in AV node mostly by S and PS

16

remodeling response is also known as

proliferative response

17

low preload

crystalloid
blood

18

bradycardia

atropine
isoproterenol
pacemaker

19

tachycardia

cadioversion
antiarrhythmic drugs

20

dec contract

epi
dopamine
dobutamine
calcium
glucagon
digoxin

21

excessive vasoconstriction

lisinopril
hydralazine
prazosin
carvedilol
nitroglycerin
nitropursside

22

excessive or abnormal contractility

metoprolol
verapamil

23

atropine sulfate avoid in
side effects

patients with glaucoma,

obstructive uropathy, gi obstruction, ileum, toxic megacolon

24

hydralazine is not

useful by itseld

25

aldosterone side effect

hyperkalemia

26

how to prevent chronic remodeling

block effects of aldoserone on cardiac tissue (spirnolactone)

block stimulation of myocardial beta-1 R SLOWLY/GENTLY

block production of AT II or ARBs

27

milk thistle

hepatoprotective by stimulating nucleolar polymerase A -->ribosomal protein synthesis

28

glucosamine

inflammation
osteoarthritis

degeneration of cartilage glycosaminoglycans

adverse- GI, headache, leg pain, edema, itching

29

GIngko

memory and concentration

improves tolerance of brain tissue to hypoxia by increasing cerebral blood flow

30

ginseng

overall health, performance, stamina enhancer--immuno stimulation

improves release of ash--CNS stim and inhib

31

garlic

atherosclerosis, high cholesterol/LDL

inhib HMG-COA reductase--increased fibrinolysis

32

ginger

anti-emetic, treatment of nausea and committing, motion sickness

interact with with 5ht R
inhibit thromboxane

33

Echinacea

treat prevent cold and flus

activate phagosomes, tnf, etc

34

St John's wort

depression, anxiety

inhibit synaptosomal uptake of 5ht, da, and NE

35

saw palmetto

benign prostatic hypertrophy, inhalammation

reduce uptake of testosterone and DHT

36

Soy

relief of symptoms and pre and post- menopause women

interact with estogren R

37

herb-drug interactions

cytochrome P450 enzymes
UGTs
P-gp

38

cheese reaction

tyramine in cheese, metabolized by MAO, if taking MAO tyramine builds up and can potentiate sump CV activity by releasing NA-->HTN response

39

TH2

associated with asthma

40

cellular action B2 agonist

B2 agonist binds R-->GPCR-->increase camp-->protein kinase-->reduces ca2+-->relaxes smooth muscle

41

3 other properties of B2 agonists

enhance mucociliary clearance
decrease microvascular permeability
suppress mediator release from inflame cells

42

Gemfibrozil

elevates liver function tests, do not use with statin

43

aspirin and plavix togehter

bruise everywhere

44

NO

nitric oxide

45

N2O

nitrous oxide

46

NO2

nitrite

47

NO2

nitrate

48

antiarrhythmics

significantly prolong depolarization (QT interval) and therefore can result in tornado de pointe as a form of pro-arrhthmia

49

only anti arrhythmic drug that proves mortality is

BETA BLOCKER

50

what is the best thing to use fir an arrhythmia

ICD

51

which class prolongs QT most

III and Ia

52

What antiarr has been shown o reduce mortality post MI?

propanolol

53

chronotropic agents

increase in HR via SA

54

positive dromotrophic agents

increase in conduction in AV node mostly innervated by S and PS

55

total cholesterol levels

desirable 240

56

LDL levels

desirable 160

57

HDL levels

desirable >50
borderline 40-50
bad <40

58

never use these drugs

Beta antg
cholinergic agonist
adenosine
aspirin and nsaids

59

ace inhibitors and asthma

dry cough

60

aminiosterioids

pancuronium
veruronium
rocuronium

61

benzylisoquinolones

cistracurium
d-tubocranine

62

Pancuronium

renal clearance

63

vecuronium

hepatic clearance

64

rocuronium

hepatic cleareance

65

cisatracurium

inactivated by plasmaChE