Flashcards in Hemostatsis/Coag Cascade Deck (81)
Loading flashcards...
1
Phases of Hematostatsis
Primary Hematostasis
Secondary Hemostatsis- coagulation phase
Termination of coag rxns
fibrinolysis
2
result of primary hemostatsis
platelet plug formation
3
result of secondary hemostatsis
fibrin formation/stabilization
4
vascular injury exposes
subendothelium (procoagulant)
5
first step of primary hemostasis
vasoconstriction
6
formation of platelet plug requires
vWF
platelets
fibrinogen
7
where is vwf synthesized
endothelial cells
megakaryocytes
8
what is vwf stored as large multimers in
weibel-palade bodies in endothelum
alpha granules in plasma cells
9
lifespan of a platelet
7-10 days
10
where is fibrinogen made
liver
11
3 categories of alpha granules
adhesive proteins
coagulant proteins
growth factors, selectins
12
adhesive proteins
fibronectin
vWF
13
coagulant proteins
fibrinogen
factor V
14
growth factors, selectins
PDGF, VEGF
P-selectin
15
dense
adp
atp
serotonin
calcium
16
Thromboxane A2
more vasoconstriction
platelet agg
platelet activation
17
fibrinogen binds to platelet via
GpIIb/IIIa R
18
platelet factor 3 activity
exposure of PS and PE on platelet surface allows coag factors to bind to platelets
19
secondary hemostasis is required to form
thrombus
20
fibrin
forms a mesh around platelets, stabilizes the platelet plus while blood vessel heals
21
coagulation factors circulate as
inactive (zymogen) as well as active forms
22
which factors are not synthesized by liver
Factor VIIII
vWF
23
what is factor VIII synthesized by
liver
vascular endothelium
24
dep on vit K for fx
2,7,9,10,S,C,Z
25
protein S, C, & Z are
endogenous anticoagulant factors
26
tissue factor
monocytes circulate in resting state and are stimulated by vascular injury to produce TF-- physiological
27
TF forms a complex w/ circulating factor VII
activation of factor VII to VIIa
28
factor Ix requires
Ca and factor 8 as cofactor to bind to platelet membrane phospholipid
--accelerates activation of factor X to Xa by 100,00 fold
29
factor 2
prothrombin
30
