Hemostatsis/Coag Cascade Flashcards Preview

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Flashcards in Hemostatsis/Coag Cascade Deck (81)
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1

Phases of Hematostatsis

Primary Hematostasis
Secondary Hemostatsis- coagulation phase
Termination of coag rxns
fibrinolysis

2

result of primary hemostatsis

platelet plug formation

3

result of secondary hemostatsis

fibrin formation/stabilization

4

vascular injury exposes

subendothelium (procoagulant)

5

first step of primary hemostasis

vasoconstriction

6

formation of platelet plug requires

vWF
platelets
fibrinogen

7

where is vwf synthesized

endothelial cells
megakaryocytes

8

what is vwf stored as large multimers in

weibel-palade bodies in endothelum
alpha granules in plasma cells

9

lifespan of a platelet

7-10 days

10

where is fibrinogen made

liver

11

3 categories of alpha granules

adhesive proteins
coagulant proteins
growth factors, selectins

12

adhesive proteins

fibronectin
vWF

13

coagulant proteins

fibrinogen
factor V

14

growth factors, selectins

PDGF, VEGF
P-selectin

15

dense

adp
atp
serotonin
calcium

16

Thromboxane A2

more vasoconstriction
platelet agg
platelet activation

17

fibrinogen binds to platelet via

GpIIb/IIIa R

18

platelet factor 3 activity

exposure of PS and PE on platelet surface allows coag factors to bind to platelets

19

secondary hemostasis is required to form

thrombus

20

fibrin

forms a mesh around platelets, stabilizes the platelet plus while blood vessel heals

21

coagulation factors circulate as

inactive (zymogen) as well as active forms

22

which factors are not synthesized by liver

Factor VIIII
vWF

23

what is factor VIII synthesized by

liver
vascular endothelium

24

dep on vit K for fx

2,7,9,10,S,C,Z

25

protein S, C, & Z are

endogenous anticoagulant factors

26

tissue factor

monocytes circulate in resting state and are stimulated by vascular injury to produce TF-- physiological

27

TF forms a complex w/ circulating factor VII

activation of factor VII to VIIa

28

factor Ix requires

Ca and factor 8 as cofactor to bind to platelet membrane phospholipid
--accelerates activation of factor X to Xa by 100,00 fold

29

factor 2

prothrombin

30

factor 2a

thrombin