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Flashcards in White blood Cell Disorders Deck (27):
0

when to worry about dysfunction

recurrent bacterial infections
infections of unusal sites
infections with unusual pathogens
chronic gingivitis or aphthous ulcers

1

4 congenital neutrophil disorders

leukocyte adhesion deficiency
hyperimmunoglobin E syndrome
chediak-higashi syndrome
chronic granulomatous disease

2

acquired neutrophil disorders

myelodysplastic syndrome
alcoholism
metabolic disorders

3

leukocyte adhesion deficiecny

adhesion and rolling (chemotactic) def; recurrent bacterial, no pus
treatment is stem cell transplant

4

hyperimmunoglobulin e syndrome

chemotaxic defect
chronic dermatitis, recurrent staph and lung infections
high Ige levels
treatment- supportive with prophylactic antibiotics

5

Chediak-Higashi syndrome

degranulation defect
recurrent pyogenic infections
children have partial albinism; treat with steroids, chemo, and stem cell transplant

6

chronic granulomatous disease

bacterial killing defect- inability to generate neutrophil oxidative burst
recurrent infections of skin and lungs with granulomas
treatment- antibiotic prophylaxis

7

primary job of eosinophils

kill parasites

8

siginificant eosinophilia

absolute eosinophil count >1500 cells/ml for > 6 weeks

9

severe eosinophilia

>5000 cells/ ul

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most common cause eosinophilia worldwide

parasitic infections

11

most common cause of eosinophilia in developed countries

atopic allergic diseases

12

causes of eosinophilia

N-neoplasm (hodgkins, lymphoma, CML, primary eosinophilic disorders)
allergies (drugs, environmental allergens
asthma
Collagen vascular diseases & vasculitis
Parsitic infections

13

acute eosinophilic leukemia

rare variant of acute myeloid leukemia

14

chronic eosinophilic leukemia

some have FIP1L1/PDGFRA mutation that responds to tyrosine kinase inhibitor treatment with imatinib

15

diagnostic appraoch for eosinophilia

complete H&P
CBC
serial stools
connective tissue serological studies such as ANA
bone marrow or tissue biopsy

16

basophils

uncommon cell that functions in hypersensitivity reactions
releases histamine and leukotrienes

17

basophilia=

CML

18

monocytes

phagocytes that release granules to kill microrganisms
precursors to macrophages, histocytes, dendritic cells

19

causes of monocytosis

chronic infections, bone marrow recovery after chemo, autoimmune/ct disorders, granulomatous disorders, malignancy

20

causes monocytopenia

uncommon but seen with severe infections
bone marrow failure states
hairy cell leukemia

21

first thing to do to establish if it is a primary lymphoproliferative disorder

establish clonality

22

establish clonality of B cells

flow cytometry for cell surface markers; they will be light chain restricted ratio will be k:l with either K or L high

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cell surface marker all B cells have

cd 20

24

clonality in T cells

PCR or westernblot

25

causes of lymphocytopenia

congenital (wiskott-aldrich syndrome)
infectious
medication
hematologic malignancies

26

pancytopenia

all three cell lines down