Heme Flashcards
1
Q
plasma cell mylignancy is known as:
A
Multiple Myeloma
2
Q
tx for Immune Thrombocytopenic Purpura:
A
usually self limiting
Steroids
IVIG
3
Q
tx for Von Willebrand’s Disease is:
A
Desmopressin
Pressing Von Willibreands
4
Q
vitamin which inhances the absorption of Iron is:
A
Vit. C
5
Q
premature breakdown of RBC is known as:
A
Hemolytic Anemia
6
Q
important maintance tx for pt with Sickle Cell Dz is:
A
Vaccination
Menigococcal
Pneumococcal
H. influenza
Influenza
7
Q
Basophilic strippling is seen in:
A
lead poisoning
8
Q
Cobalamin deficiency is seen in:
A
B12 deficiiency
CoB12alamin
9
Q
Painless lymphadenopathy
Older patient
Chronic immunocompromised pt.
night sweats
A
Non-hodgkins lymphoma
10
Q
Clotting factor 7 is extrinsic or intrinsic?
A
extrinsic = seven
11
Q
Ferritin is:
A
stores iron in the liver
12
Q
absorption of B12 requires binding to:
A
Gastric Instrinsic Factor
13
Q
Coombs test is done to:
A
r/o autoimmune causes of RBC destruction (hemolytic anemia)
14
Q
the mechanism of action of Von Willebrand factor:
A
attaches to platelletes causing agregation and adhesion
agregating and adhessive Von Willebrand
15
Q
most common lymphoma in the young adults is:
A
Hodgkin’s lymphoma
16
Q
elements that decreases the absorption of Iron is:
A
Calcium
17
Q
common manifistations of sickle cell Dz:
A
infections
pigmented gallstones
spenomegally
leg ulcers
dyctylitis
priapism
chronic osteomyelitis due to salmonella
renal failure
18
Q
major adult hgb is:
A
Hgb A
19
Q
Rouleax appearnce / stack of coins is seen in:
A
Multiple Myeloma
20
Q
prolifiration of B lymphocytes is present in
A
CLL
B lymphocytic CLL
21
Q
significant lab finding in CML is:
A
increased WBC
22
Q
most lympomas are
A
Non Hodgkins
23
Q
Adult with Sickle Cell Dz.
acute chest pain
wheezing
A
Acute Chest Syndrome
24
Q
tx of Fe deficiency
A
oral Ferrous Sulfate 325 mg
25
Transition of CML to ALL is known as:
**Blast Crisis**
26
**autoimmune destruction of platelets** after a recent infection is idicative of:
**Immune Thrombocytopenia Purpura**
27
**spherical** RBC
**spherocyte** seen on smear
are indicative of:
Hereditary spherocytosis
28
**Hgb H disease** is:
Alpha thalassemia with 3 out of 4 genes being abnormal
H disease = alpha thalassemia
**(HA)**
29
most common cause of Iron deficiency anemia:
**GI bleed**
**Menstral cycle**
30
Thrombocytopenias that will produce **Shistocytes**:
Thrombotic Thrombocytopenic Purpura
Hemolytic Uremic Syndrome
Disseminated Intravascular Coagulation
31
most common inherited bleeding disorder is:
**Von Williebrand Disease**
32
most sever type of B Thalassemia is:
**Cooley's anemia** - B-Thalassemia major
33
Spontanious hemathrosis (bleeding into joins) is a sign of:
Hemophilia
34
Philadelphia Chromostome abnormality (9 & 22) is a sign of:
Chronic Myeloid Leukemia
**CML=Philadel**
35
Most common cause of **microcytic anemia** is:
**Fe** deficiancy
36
MoA of Desmopressin is:
**stimulation** of **Von Willebrand** factor secretion
***Desmopressin stimulates Von Willebrnand to secrete factors***
37
tx for B-Thalassemia Major is:
chronic transfussion
with Iron chelation to avoid hemochromotosis
38
**Elevated Homocysteine and normal methylmalonic** levels are indicative of:
**Folic Acid** deficiency
39
**Hymolytic anemia** will show what ritculocyte count?
high reticulocytes
RPI\>2
40
abnormal bleeding parameter in Hemophelia is:
PTT
41
Alpha and Beta Thalassemia
what ethnic groups?
**Alpha \> Asian**
**Beta \> Meditrrenia**
42
Methylmalonic Acid is or is not elevated in folace deficiency anemia?
Folate deficiency = normal Methlmalonic Acid
43
BCR/ABL gene detected
CML
44
facial malformations,
cognitive delays,
severe anemia,
bone disease/osteopenia
corresponds to what type of **Beta Thalassemia**?
**Beta - Thalassemia Major**
**(Cooley's anemia)**
45
sicle cell dz pt should take what suppliment?
folic acid
46
**Smudge** cell are seen in:
**CLL**
**smudge CLL**
47
Deficiency of Folic Acid is connected to:
Alco**Folic** abuse
48
**Schilling** test differentiates:
problems w B12 **instrinsic factor (pernicious anemia)**
from other causes of B12 deficiency
49
pt with meditranian origin have higher risk of developing what kind **Thalassemia?**
Beta - Thalassemia
## Footnote
**Meditrenian Beta**
50
Anemia of Chronic Disease will produce
**Normocytic Anemia**
51
**HyperSegmented Neutrophils** are seen in:
**B12** anemia
## Footnote
**hypersegmented B12**
52
**Favism** is:
intravascular hemolysis caused by ingestion of **Fava beans**
53
Sickle Cell Anemia is diagnosed with:
Electrophoresis
54
**Thalassemia** will produce what kinds of anemia?
Microcytic
55
Thrombocytopenia which is caused by:
pregnancy
HIV
Cyclosporins
Quinidine
Thrombotic Thrombocytopenic Purpura (TTP)
56
**pain in the lymph nodes after alchohol** is seen in:
Hodgkins Lymphoma
57
drugs that induce **hemolytic anemia** through **oxidative stres**s in pt with G6PD:
Antimalaria: -quine-, **daspone**
ASA
Sulfa
Nitrofurantoion
58
**Hgb A** is made of:
2 alpha chains
+
2 beta chains
59
Howell-Jolly bodies are seen in
Sickle Cell Dz
## Footnote
**Jolly Sickle**
60
fast **bone marrow failure** with blast seen on the smear is indicative of:
**acute leukemia**
61
common deficiency seen in pt with Sickle Cell Dz is:
**Folic Acid**
**sickle folic acid deficiency**
62
**Auer Rods** are seen in:
Acute Myeloid Leukemia (AML)
63
**Pernicious Anemia** reffers to:
autoimmune attack on gastric instrinsic factor
causes malabsorption of **B12**
64
side effect of methotrixate is:
folic acid antagonist
will produce megaloblastic anemia.
65
Most common type of leukemia is:
**Chronic Lymphocytic Leukemia**
66
sx of Hodgink's lymphoma
night sweats
67
Tx of Anemia of Chronic Dz:
**Erythropoietin** (stimmulate bome marrow to produce) RBC
68
Lab values in Anemia of Chronic Disease
| (Fe, Ferritin, Reticulocytes)
low Fe
hight Ferritin
low Reticulocytes
69
abnormal coagulation after a serious injury, sepsis, burns, truama is known as:
**Disseminated Intravscular Coagulation (DIC)**
70
**Chronic Microcystic Anemia** with **various severity** of sx is seen in what Alpha Thalassemia?
**Hemoglobin H disease**
71
Acute Sickle Cell Anemia is precipitated by:
Infection
Stress
Dehydration
High altitude
Hypoxia
low pH
72
what effect Hashimoto Dz (Hypothyroidism) will have on hememotology:
**Development of Pernicious Anemia**
73
**Bence-Jones** protein seen in urine is a sign of:
Multiple Myeloma
## Footnote
**Multiple Bence-Jones**
74
Neurolgocial sx are present in what type of Macrocytic Anemia:
**B12** deficiency
75
Hereditary spherocytosis is:
dominant disorder
resutls in spherocytic RBC
which are being destryed by spleen
**LEADS to: hemolytic anemia.**
76
Anemica of Chronic Disease is caused by:
**Inflammation**
77
Conditions where bone marrow does not produce
WBC, RBC, Pletallets (**all cell lines are deminished**) is known as:
**Aplastic Anemia**
78
D dimers will be ______ in **Dissemented Intravascular Coagulation**
**elevated D dimers**
79
presentation of **Thrombotic Thrombocytopenic Purpura** (TTP)
**FAT\_RN**
Fever
Anemia
Thrombocytopenia
Renal sx
Neurological sx
80
pt with Sickle Cell Dz are prone to what types of microrganisms?
**Encapsulated**
81
**I**solated **T**hrombocytopenia in **P**eds
recent viral infection
petechial hemorrhage
mucosal bleeding
**Immune/idiopathic Thrombocytopenic Purpura (ITP)**
**I**solated **T**hrombocytopenia in **P**eds = ITP
82
which factors are missing in Hemophilia A & B
**Hem A - factor 8**
**Hem B - factor 9**
83
Most common Leukemia in children
**Acute Lymphocytic Leukiemia** (ALL)
## Footnote
**ALL CHILDREN**
84
**blast** seen on the smear is indicative of:
acute leukemia
85
**Ebstain Bar** virus is linked to:
Hodgkin's Lymphoma
86
**Methylmalonic** Acid elevated only in:
**B12 **deficiency
87
child with sickle cell dz.
acute LUQ pain
Spleenomegaly
Fever
State of shock
all indicated of:
**Spleenic Sequestration Syndrome**
88
lab values seen in **Hemolytic anemia**:
**high** LHD
**high** indirect bilirub
**reduced** haptaglobin
89
presence of **Hemoglobin S** is indicative of:
**Sickle Cell Dz**
Hgb **S** = **S**ickle cell dz.
90
neuro sx seen in B12 deficiency:
paresthesias
gait disturbance
vibratory sence
91
Acute Leukemia seen in adults is known as:
**Acute Myeloid Leukemia**
**M**yeloid - **Mature adults**
**L**ymphocitic - **Little children**
92
**+ Coombs** test is indicative of:
**atibodies** that attach to and destroy RBC
93
tx for Spherocytosis is:
spleenectomy
94
Loss of all 4 alpha chain hgb genes results in:
hydrops fetals
95
Neurolgocial sx are **NOT** present in what type of Macrocytic Anemia:
**Follic Acid Deficiency**
96
**Bite** Cells
**Heinz** bodies
are indicative of:
**G6PD**
**Heinz Bite Glucose 6 PD**
97
**Reed Sternberg** cells are indicative of:
Hodgkins Lymphoma
98
pt presents with **pancytopenia** severe:
anemia **(anemia)**
bleeding **(thrombocytopenia)**
infection **(leukopenia)**
**Aplastic Anemia**
99
**B12** is absorpbed in:
***terminal ileum***
100
Reduction in RBC production by bone marrow is seen in:
Anemia of Chronic DZ
101
**Lytic bone** lesions seen on X ray is indicative of:
**Multiple Myeloma**
102
**F**ever
**A**nemia
**T**hrombocytopenia
**R**enal impairment
**N**eurologic abn
**FAT\_RN**
**presentation of:**
**Thrombotic Thrombocytopenic Purpura (TTP)**
103
low Hgb A
high Hgb F
high Hgb A2
indicative of:
**Beta Thalassemia**
104
**G6PD** is often seen in:
African American
Asian
Meditranians
105
tx for CML is:
**Imatinib** (tyrosine kinase inhibitor))
106
when switching from IM dosage of 1000 **Cobalamin (B12)** to oral, the dosage needs to be:
doubled to **2000 units.**
107
**_Favism_** is seen in pt with:
**G6PD**
108
**factor V lieden** mutation results in:
**HyperCoagulation**
DVTs
PE
109
**Positive Osmotic Fragility** test is indicative of:
**Hereditary Spherocytosis**
110
**earliest & best** indicator of Fe deficiency is
**low Ferritin**
111
what hemoglobin changes occure in **Sickle Cell anemia**:
hgb **Beta** is subtituted with hgb **S**
112
condition that cause **B12** deficiency:
Vegans (intake of meat)
Gastrectomy (absroption)
Chron's Dz (absorption)
Instrinsic Factor
113
reduced **heptaglobin** is a sign of:
Hemolytic anemia
114
elevated Ferrotin
Chronic inflamation
Hepcidin and inflammatory cytokine (IL6)
low Fe
indicative of:
**anemia of chronic disease**
115
complete lack of beta hgb chains is known as:
**Cooley's anemia** - Beta Thalassemia major
116
Positive **Schilling Test** is indicative of:
**B12** deficiency
117
organism commonly found in pt. **with sicle cell dz**?
**Step Pneumonia**
**H. Influenza**
**Salmonella**
**Parvovirus 19**
118
Methylmalonic Acid elevated in _____ anemia while
Homocystine is elevated in _________ anemia.
**Meathlmalonic** \>**B12**
**Homocystine**\> B12 **_and_** Folate
119
Restless leg syndrome is seen in what deficiency?
Iron
120
prophylactic tx of children who had spleen removed due to Sickle Cell Diz is:
daily peniciilin
121
Spleen is responsible for production of what antibodies?
**IgM**
| (opsonize encapsulated bacteria)
