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Flashcards in heme Deck (82)
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1

mechanism of warfarin

inhibits vitamin K dependent carboxylation of glutamic acid residues for

factors II, VII, IX, X

2

What is the central regulator for iron storage and release

Hepcidin by interaction with ferroportin

3

Where is Hepcidin synthesized and secreted?

hepatic parenchymal cells

4

What is methemoglobin

when Fe 2+ in heme is oxidized to Fe2+

5

What causes methemoglobinemia?

drugs (nitrites, dapsone)
enzyme deficiencies and hemoglobinopathies

6

Pancytopenia with fatty looking bone marrow

aplastic anemia

7

What tissue does parvovirus B19 replicate in?

bone marrow

8

Why can't mature RBCs synthesize heme?

no mitochondria

9

What to give to reverse warfarin?

fresh frozen plasma

10

what to give to reverse heparin

protamine

11

child with blast cells on peripheral blood smear
dysphagia, dyspnea

What neoplastic cell is responsible?

Acute lymphobastic leukemia, T lymphocyte type

dysphagia, dyspnea--> mediastinal mass compressing on trachea and esophagus (thymus is in medistinum and where T cells mature)

12

what chromosomal abnormalitiy with Auer rods

t (15;17)

AML, M3 variant

13

what amino acid substitution in Sickle cell anemia?

glutamic acid--> valine

14

What does enoxaparin bind?

binds antithrombin IIII

low molecular weight heparin, acts like heparin

15

anemia with spoon nails and dysphagia

Fe deficiency anemia

16

What protein does EBV bind to on B cells

CD21

binds EBV gp350

17

irreversibile inhibitor of COX1 and COX2

ASA

18

What is the structure of parvovirus B19

non enveloped
single stranded DNA

19

What enzymes are required to convert fructose 6 phospate to ribose?

transaldolase--> glyceraldehyde 3 P
transketolase--> ribose 5 phosepate

20

What causes the green color of a healing hematoma?

heme oxygenase converting heme to biliverdin (green)

21

what drugs enhance P450?

rifampicin
phenobarbital
phenytoin

22

What drugs inhibit P450

cimetidine
amiodarone
TMP-SMX
isonizad

23

What kind of drug is celecoxib

COX2 inhibitor

24

What is the advantage of COX2 inhibitors over traditional NSAIDs?

less risk of GI bleeds and ulcers

25

what does PT measure?

extrinsic pathway
factors I, II, V, VII, X

26

What does PTT measure

intrinsic pathway
all factors except VII and XIII

27

Where is the defect in hemophilia A

factor VIII

28

where is the defect in hemophilia B

IX

29

coagulation labs for a person on hemodialysis

accumulation of uremic toxins impairs platelet aggregation and adhesion

prolonged bleeding time
normal PT
normal PTT
normal platelet count

30

prolonged bleeding and bleeding in joints is suggestive of what disease

hemophilia