Flashcards in heme Deck (82)
mechanism of warfarin
inhibits vitamin K dependent carboxylation of glutamic acid residues for
factors II, VII, IX, X
What is the central regulator for iron storage and release
Hepcidin by interaction with ferroportin
Where is Hepcidin synthesized and secreted?
hepatic parenchymal cells
What is methemoglobin
when Fe 2+ in heme is oxidized to Fe2+
What causes methemoglobinemia?
drugs (nitrites, dapsone)
enzyme deficiencies and hemoglobinopathies
Pancytopenia with fatty looking bone marrow
What tissue does parvovirus B19 replicate in?
Why can't mature RBCs synthesize heme?
What to give to reverse warfarin?
fresh frozen plasma
what to give to reverse heparin
child with blast cells on peripheral blood smear
What neoplastic cell is responsible?
Acute lymphobastic leukemia, T lymphocyte type
dysphagia, dyspnea--> mediastinal mass compressing on trachea and esophagus (thymus is in medistinum and where T cells mature)
what chromosomal abnormalitiy with Auer rods
AML, M3 variant
what amino acid substitution in Sickle cell anemia?
glutamic acid--> valine
What does enoxaparin bind?
binds antithrombin IIII
low molecular weight heparin, acts like heparin
anemia with spoon nails and dysphagia
Fe deficiency anemia
What protein does EBV bind to on B cells
binds EBV gp350
irreversibile inhibitor of COX1 and COX2
What is the structure of parvovirus B19
single stranded DNA
What enzymes are required to convert fructose 6 phospate to ribose?
transaldolase--> glyceraldehyde 3 P
transketolase--> ribose 5 phosepate
What causes the green color of a healing hematoma?
heme oxygenase converting heme to biliverdin (green)
what drugs enhance P450?
What drugs inhibit P450
What kind of drug is celecoxib
What is the advantage of COX2 inhibitors over traditional NSAIDs?
less risk of GI bleeds and ulcers
what does PT measure?
factors I, II, V, VII, X
What does PTT measure
all factors except VII and XIII
Where is the defect in hemophilia A
where is the defect in hemophilia B
coagulation labs for a person on hemodialysis
accumulation of uremic toxins impairs platelet aggregation and adhesion
prolonged bleeding time
normal platelet count