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Flashcards in MSK Deck (63)
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1

first line treatment for acute gout

NSAIDs
second line: cochicine.
do not use allopurinol because it can make it worse

2

Injury causing axillary nerve damage

dislocation of humerus (anterior is most common)

3

positive HLA B27

ankylosing spondylitis

4

what do you need to routinely check in ankylosing spondylitis?

chest expansion

pain can lead to decreased chest wall expansion and hypoventilation

5

cause of vitiligo

loss epidermal melanocytes

6

explain myopia improving with age

lens elasticity decreases with age--> cannot focus on near objects (prebyopia)
but if you have myopia, this results in retaining near vision and some improvement in myopia.

7

what causes wrinkles?

decreases synthesis of dermal collagen and elastin

8

female with persistent back pain, fatigue, poor sleep. pain worsens with exercise

fibromyalgia

9

obturator nerve damage
injury
motor deficit
sensory deficit

injury: anterior hip dislocation
motor: thigh adduction
sensory: medial thigh

10

femoral nerve damage
injury
motor deficit
sensory deficit

injury: pelvic fracture
motor: thigh flexion and leg extension
sensory: anterior thigh and medial leg

11

greatest factor in determining peak bone mass

genetic factors

12

course of median nerve through the arm

between biceps brachii and brachialis
between humeral and ulnar heads of pronator teres
between flexor digitorum superficialis and flexor digitorum profundus muscles
enters wrist

13

function of small nuclear ribonucleoprotein (snRNP)

splices introns out of mRNA. works in spliceosomes

14

RNA fragment with dihydrouracil, thymidine, and acetylcytosine residues

tRNA (has weird nucleosides)
ends in CAA before where amino acid attaches to OH

15

Etanercept mechanism

TNF decoy receptor that binds TNF alpha

16

actinic keratosis predisposes to

squamous cell carcinoma

17

side effects of colchicine

GI distress (especially when given orally)

18

mechanism of colchicine

binds intracellular tublin preventing polymerization into microtubules--> impairs leukocyte migration and phagocytosis (decreasing inflammation)

effect on GI cells causes side effects of GI upset

19

common peroneal nerve damage
injury
motor deficit
sensory deficit

injury: trauma to lateral aspect of leg or fibula neck fracture
motor deficit: foot eversion and dorsiflexion, toe extension, food drop, foot slappage, steppage gait
sensory deficit: anterolateral leg and dorsal aspect of foot

20

tibial nerve damage

injury: knee trauma
motor deficit: foot inversion and plantar flexion, toe flexion
sensory deficit: sole of foot

21

superior gluteal nerve damage
injury
motor deficit

injury: posterior hip dislocation or polio
motor deficit: thigh abduction (positive trendelenburg)

22

inferior gluteal
injury
motor deficit

injury: posterior hip dislocation
motor deficit: can't jump clib stairs, rise fro seated position, cannot push downward (inferiorly)

23

chronic lymphedema increases risk for?

angiosarcoma

24

baby with flaccid lower extremities, absent lower extremity reflexes and poorly developed lumbar and sacral spine

caudal regression syndrome
may also have urinary incontinence and anal atresia

associated with poorly controlled maternal diabetes

25

muscles used for sitting up (flexion)

external abdominal obliques
rectus abdominis
iliopsoas

26

what kind of glands does smelly sweat come from?

apocrine glands

27

alkaptonuria

lack of homogentisic oxidase blocking metabolism of phenylalanine and tyrosine

build up of homogentistic oxidase

tyrosine cannot be converted to fumerate

28

amino acid sequence of collagen

Gly-X-Y

XY may be proline or lysine

29

mechanism of Osteogenesis imperfecta

defective synthesis of collagen type1
problem with bone matrix formation

30

histology of contact dermititis

spongiosis