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Flashcards in immuno Deck (32)
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1

where do you find macrophages in LN

medullary sinus

2

where do you find T cells in LN

paracortex

3

where do you find B cells in LN

follicle of cortex

pale central germinal are where they are actively differentiating with isotype switching

4

where do you find T cells in the spleen

PALS
periaterial lymphatic sheath

5

where are B cells in the spleen

germinal centers in the white pulp

6

cell markers for macrophages

CD 14, CD40, MHC 2, B7

7

cell markers for B cells

CD 19, 20, 21 (receptor for EBV)
CD40 MHC 2, B7

8

cerebellar defects (ataxia)
spider angiomas
IgA deficiency

Ataxia telangitasias

defect in ATM, DNA repair gene. Very sensitive to ionizing radiation

9

what cell prevents hematogenous spread of candida

neutrophils

10

What is released from the mitochondria during intrinsic pathway apoptosis

cytochrome c

11

proximal muscle weakness
muscle bx shows MHC I overexpression on the sarcolemma and CD8 lymphcyte proliferation

polymyositis

12

urethritis, arthritis, conjunctivitis

reactive arthritis, associated with sacroilitis

HLA B27

13

delayed separation of the umbilical cord

leukocyte adhesion deficiency type 1--> defective LFA-1 integrin

14

sore throat and fever with cervical lymphadenopathy and splenomegaly

peripheral blood smear shows large lymphocytes with edges conforming to neighboring cells

EBV
these are CD8 cytotoxic T cells

15

what kind of Ig is anti D (Rh)?

IgG

16

describe mechanism of acute rejection

Host T cell sensitization against graft MHC (happens fast)

17

What is rheumatoid factor?

IgM Ab against Fc of self Ig

18

recurrent viral, bacterial, fungal, and protozoal infections
no thymus

SCID

can be caused by adenosine deaminase deficiency

19

Thrombocytic purpura
infections
Ezcema

Wiskott-Aldrich syndrome

decreased IgM
increased IgE, IgA

20

What proteins are necessary on a cell to be infected by HIV

CD4
CCR5 (chemokine receptor)

21

histology of acute rejection

dense interstitial infiltrate

22

histology of chronic rejection

fibrosis of graft tissue and blood vessels (obliterative vascular fibrosis)

23

recurrent bacterial infections after 6mo
absence of thymic shadow
decreased B cells and Ig

Bruton's agammaglobulinemia
X linked recessive
blocks pro B cells from forming pre B cells

24

IL-12 receptor deficiency tx

no IL12 receptor--> decreased TH1--> decreased IFN gamma

25

facies
non inflammed staph abcess
retained primary teeth
eczema
increased IgE

hyper IgE

cells cannot make IFN gamma--> decreased suppression of TH2--> increased IgE

26

frequent infections by catalase positive organisms
negative nitroblye tetrazolium dye reduction test on neutrophils

Chronic granulomatous disease

not producing NADPH oxidase--> decreased oxygen species

27

mechanism of hyper IgM syndrome

defective CD40L on helper T cells--> cannot bind B cells and induce class switching--> can only make IgM

no switching--> no germinal centers in LN (where B cells differentiate)

28

cell marker for NK cells

CD56, CD16

29

inhibitory cytokines

TGF beta
IL10 (from Th2 inhibiting Th1)
IFN gamma (from Th1 suppressing Th2)

30

albanism
recurrent staph and strep infections
peripheral neuropathy

Chediak-Higashi

defect in fusion of lysosome and phagosome