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Flashcards in Heme/Onc Deck (36):
1

Elderly M with hypochromic microcytic anemia is asxic. Dxic tests?

FOBT and sigmoidoscopy; suspect CRC

2

Precipitants of hemolytic crisis in pts with G6PD deficiency

Sulfonamides, antimalarial drugs, fava beans ("HEMOLYSIS IS D PAIN And No Fun")

3

MC inherited cause of hypercoagulability

Factor V Leiden mutn

4

MC inherited bleeding d/o

von Willebrand's dz

5

MC inherited hemolytic anemia

Hereditary spherocytosis

6

Dxic test for hereditary spherocytosis

Osmotic fragility test

7

Pure RBC aplasia

Diamond-Blackfan anemia

8

Anemia a/w absent radii and thumbs, diffuse hyperpigmentation, café au lait spots, microcephaly, and pancytopenia

Fanconi's anemia

9

Meds and viruses that lead to aplastic anemia

Chloramphenicol, sulfonamides, radiation, HIV, chemo, hepatitis, parvovirus B19, EBV

10

How to distinguish polycythemia vera from 2˚ polycythemia

-Both: increased Hct and RBC mass
-Polycythemia vera: normal O2 sat, low EPO levels

11

Thrombotic thrombocytopenic purpura (TTP) pentad

"FAT RN": Fever, Anemia, TCP, Renal dysfcn, Neurologic abnlities

12

HUS triad

Anemia, TCP, acute renal failure

13

Tx for TTP

-Emergent large-volume plasmapheresis
-Corticosteroids
-Antiplatelet drugs

14

Tx for idiopathic thrombocytopenic purpura (ITP) in kids

-Usually resolves spontaneously
-May require IVIG and/or corticosteroids

15

Which of the following are increased in DIC: fibrin split products, D-dimer, fibrinogen, plts, Hct

-Elevated: fibrin split products, D-dimer
-Decreased: plts, fibrinogen, Hct

16

8 yo M presents with hemarthrosis and increased PTT with normal PT and bleeding time. Dx? Tx?

-Dx: hemophilia A or B
-Tx: consider desmopressin (for hemophilia A) or factor VIII or IX supplements

17

14 yo F presents with prolonged bleeding after dental surgery and with menses. Nl PT, nl or increased PTT, and increased bleeding time. Dx? Tx?

-Dx: von Willebrand's dz
-Tx: desmopressin, FFP, or cryoprecipitate

18

4 causes of microcytic anemia

"TICS": Thalassemia, Iron deficiency, anemia of Chronic dz, and Sideroblastic anemia

19

60 yo AAM presents with b. pain. W/u for multiple myeloma might reveal ___.

Monoclonal gammopathy, Bence Jones proteinuria, "punched-out" lesions on XR of skull and long bb.

20

Reed-Sternberg cells

Hodgkin's lymphoma

21

10 yo M presents with fever, wt loss, and night sweats
Exam: anterior mediastinal mass
Suspected dx?

Non-Hodgkin's lymphoma

22

Microcytic anemia with
-Decreased: serum iron, TIBC
-Normal or increased: ferritin

Anemia of chronic dz

23

Microcytic anemia with
-Decreased: serum iron, ferritin
-Increased: TIBC

Iron deficiency anemia (IDA)

24

80 yo M presents with fatigue, LAD, splenomegaly, and isolated lymphocytosis. Suspected dx?

Chronic lymphocytic leukemia (CLL)

25

Lymphoma equivalent of CLL

Small lymphocytic lymphoma

26

Late, life-threatening complication of chronic myelogenous leukemia (CML)

Blast crisis (fever, b. pain, splenomegaly, pancytopenia)

27

Auer rods on blood smear

Acute myelogenous leukemia (AML)

28

AML subtype a/w DIC

M3

29

Lyte ∆s in tumor lysis syndrome

-Decreased: Ca2+
-Increased: K+, phosphate, uric acid

30

Tx for AML M3

Retinoic acid

31

50 yo M presents with early satiety, splenomegaly, and bleeding. Cytogenics show t(9;22). Dx?

CML

32

Heinz bodies

Intracellular inclusions seen in thalassemia, G6PD deficiency, and post-splenectomy

33

AR d/o with a defect in the GPIIbIIIa platelet R and decreased plt aggregation

Glanzmann's thrombasthenia

34

Virus a/w aplastic anemia in pts with sickle cell anemia

Parvovirus B19

35

25 yo AAM with sickle cell anemia has sudden onset of b. pain. Management of pain crisis?

-O2
-Analgesia
-Hydration
-Transfusion (if severe)

36

Significant cause of morbidity in thalassemia pts. Tx?

Iron overload. Tx with deferoxamine.