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COMLEX 2 > Heme/Onc > Flashcards

Flashcards in Heme/Onc Deck (32):
1

Auer Rods

AML

2

Philly Chromosome 9:22

CML

3

Sickle Cell Trait patients commonly get...

Hematuria secondary to renal papillary necrosis

4

Burkitt Lymphoma

t(8,14) c-myc Sporadic Burkitt Lymphoma is seen in Western Hemisphere: abdominal mass, ascites, tumor lysis syndrome with elevated LDH + uric acid Endemic Burkitt Lymphoma is seen in Africa: jaw/facial tumors with extranodal spread to other organs

5

Multiple myeloma - most common finding on echocardiography

decreased stroke volume secondary to excessive protein buildup causing restrictive cardiomyopathy

6

Small Cell Lung Ca. keywords

large hilar mass (central nodular lesion) bilat hilar adenopathy smoking

Hypercortisol

HypOnatremia

7

Papillary thyroid ca. _____ of all thyroid ca.

74-80%

8

Trisomy 21 is associated with an increased risk of

ALL

9

Von Willebrand Disease Lab

Inc. PTT Inc. BT

10

Hairy Cell Leukemia keywords

TRAP+ splenomegaly + pancytopenia Tx: Nucleoside analogs

11

Squamous cell ca. associated risk factor? Produces what? Located where?

Smoking

Hilar (centrally located)

PTHrP --> hypercalcemia

12

Fanconi Anemia Inheritance? D/t? Tx?

S&S: aplastic anemia, abnormal thumbs, cafe au lait, large freckles, deafness AutoRec. d/t chromosomal breaks on genetic analysis Tx: Hematopoietic stem cell transplant

13

DIC labs

Decreased Fibrinogen, Factor II, V, VIII, platelets Increased PT/PTT, D-dimer

14

Graft-Versus-Host Disease Tx?

maculopapular rash, GI symptoms, hepatic dysfunction in a pt. who recently underwent a transplant Methylprednisolone (suppresses cytokine release)

15

Labs in B12 Deficiency

Inc. MMA Inc. Homocysteine

16

Labs in Folate Deficiency

Inc. Homocysteine

17

Tx. for AML puts patients at risk for?

Tumor Lysis Syndrome: hyperkalemia/phosphatemia/uricemia/

18

Tx. Beta Thal Major

Packed RBC transfusions

19

Ependymoma Tx

Surgery then radiotherapy (Lumbar Puncture is contraindicated due to risk of herniation.)

20

Rituximab MOA Tx for what diseases?

Anti-B cell med Tx for: B cell lymphoma, CLL, ITP, RA, Refractory Lupus Nephritis, Waldenstrom's, Wegener's (granulomatosis w/ polyangiitis)

21

Cyclosporine MOA

IL-2 Inhibitor Tx for Solid organ transplant

22

Tx. for Acute DVT

IV Heparin (not SQ)

23

Coagulation Cascade

A image thumb
24

What is thrombopoietin?

 

What is it's level in Polycythemia Vera?

Megakaryocyte growth factor.

 

Thrombopoietin is decreased in P-vera because since body's making a lot of erythroid precursors, it's also making a lot of platelet precursors, thereby negative feedbacking on thrombopoietin to decrease it.

25

Heparin's MOA?

Effects on coagulation cascade?

activates Antithrombin III, affecting Intrinsic Pathway (PITT)

↑ PTT

26

Coumadin's MOA?

Effects on coagulation cascade?

Inhibits Vit. K (2, 7, 9, 10, C, S), affects Extrinsic Pathway (PET)

PT

27

LMWH's MOA?

Effects on coagulation cascade?

Inhibits Factor Xa

28

Antiphospholipid Syndrome (Hughes Syndrome)

29

Hemophilia 

 

Tx?

Concentrated Factor 8

Cryoprecipitate (contains Factor 8, Fibrinogen, Fibronectin, Factor 13, and vWF)

DDAVP (for MILD hemophilia) 

30

Idiopathic Thrombocytopenic Purpura (ITP)

Often young children with isolated thrombocytopenia

 

Tx: Glucocorticoids and IV Ig

31

Thrombotic Thrombocytopenic Purpura (TTP) keywords

Thrombocytopenia

Anemia

Renal Failure

Seizures, Altered mental status

32

Adenocarcinoma keywords

 women

non-smoking

peripheral