hemeonc1

Question 1

lymphocytes with cytoplasmic inclusions

Answer 1

hairy cell leukemia

Question 2

decreased fibrinogen levels seen in

Answer 2

DIC

Question 3

materinal blood type A and B ; isoimmunization does not occur bc

Answer 3

naturally occuring antibodies anti A and B are of IgM type; cannot cross placenta.’t

type O have antibodies that are predominatly of IgG type, which can cross placenta

Question 4

indirect hyperbilirbuine, elevated LDh, spherocytes; + direct coomb

Answer 4

Autoimmune hemolytic anemia

Question 5

what lowers hepcidin levels

Answer 5

hypoxia and increaed erythropoiesis

Question 6

uremia bleeding studies

uremic toxins imair platelet aggregation and adhesion

Answer 6

PT: normal
PTT: normal
platelt count: normal
bleeding time: increaessd

Question 7

EML4 and ALK fusion protein

Answer 7

Non small cell lung carcinoma

Question 8

hard lymph nodes palpated in right inguinal area inferior to inguilal ligament. comes from what original site

Answer 8

orifice of anal canal

superifical inguinal lymph notes

Question 9

upper third of rectum drains into

Answer 9

inferior mesenteric lymph nodes

Question 10

increased expression of PD-1 ligand does what

Answer 10

binds to Pd1 receptor on cytotoxic T cells; inhibiting ability to induce apoptosis (T cell ehasution)

Question 11

accumulation of macrophages with fibrillary cytoplasm

Answer 11

gaucher disease

Question 12

dilated sinusoids and fibrous nodules with hemosiderin

Answer 12

congestive splenomegaly due to portal HTn

Question 13

kozak consensus squence is ued for initiation of

Answer 13

translation.

gccgccRccAUGG (R is adenonine or guanine)

Question 14

pure red cell aplasia

Answer 14

thymoma,
lymphocytic leukemia
parvovirus B19

Question 15

western blot simlar to elisa; the difference is

Answer 15

western lbot: separted by electrophoresis

ELISA: pt’s serum tested directly

Question 16

how do tumor cells adhere to basememt mebmrane

Answer 16

laminin

Question 17

increased vascular leakage in microvasculature leads to hemoconcentration and decreased wall shear stress improving contact of neutrophils w endothelial lining

Answer 17

margination

Question 18

how does tnf a cause cachexia

Answer 18

appetite suppression

increase basal metabolic rate

Question 19

HER2 oncogene encodes for

Answer 19

transembmrane glycoprotein w intrinsic tyrosine kinase activity; causes accelerated cell proliferation

Question 20

ionizing radiation for cancer causes cell death trhough 2 mechanisms

Answer 20

1. double strand dna breakage

2. free radical formation

Question 21

caseating granulomas of TB : large epithelioid macs w pale pink granular cytoplasm and surface CD ___ at periphery

Answer 21

CD14

Question 22

marker of monocyte-macrophage cell lineage

Answer 22

CD14

Question 23

ITP vs vwf disease

Answer 23

ITP : not chronic

vwf: chronicc, unreletning since childhood

Question 24

spleen in aplastic anemia

Answer 24

ABSENT SPLENOMEGALY

Question 25

hypercellular marrow w increased blstsa

Answer 25

myeloprolifearitve disorders : 1 myelfoibrosis

Question 26

pancytopenia; proteinuria, rbc cast

Answer 26

SLE

Question 27

primary myelofibrosis and myelodysplastic syndrome commonly seen in pt's over

Answer 27

50

Question 28

causes activating mutation

Answer 28

proto oncogene

Question 29

loss of function mutation

Answer 29

tumor suppressor

Question 30

occult blood loss occurs in the

Answer 30

GI tract

Question 31

nonsamll cell lung cancer what type of bone lesiosn

Answer 31

osteolytic

Question 32

melanoma casues what type of bone lesiosn

Answer 32

lytic bone lesions

Question 33

erythematous itchy red breast rash

Answer 33

peau d'orange

Question 34

whole blood transufsions: many of them cause levation of ___ leading to hypocalceimia

Answer 34

citrate

Question 35

if you have a low RC count, can you have extramedulerythropoiesisi

Answer 35

no

Question 36

treatment of AIP

Answer 36

glucose or heme prp downregulates ALA syntehsis dextrose inhibits peroxisome proliferator activated receptor -gamma a transcirption factor that induces sytnehsis of Ala syntehase

Question 37

small lymphoid cells w cleaved nuclei

Answer 37

follicular lymphoma

Question 38

basophilic oval inclusions in mature neutrophils

Answer 38

dohle bodies seen in leukocyte alkaline phosphate reaction

Question 39

decreased neutrohils seen in

Answer 39

CML

Question 40

amniotic fluid emoblism dic pregnancy:tissue factor maternal DIC

Answer 40

amnitofic fluid emoblis: hypotension; cardigoenic shock unlikeh tn seen in this pt

Question 41

solid and cystic component brain tumor

Answer 41

pilocytic astrocytoma

Question 42

BRCA1 and 2 involvedin

Answer 42

DNA repair (tumor suppressor geen