mechanism of 2nd infection w/dengue fever
presentation of 2nd infection w/dengue fever
antibodies from 1st dengue fever infection cross-react with new dengue infection; Fc receptor on these antibodies are taken to mononuclear cells where dengue infects!
2nd infections are more sever and can cause dengue hemorrhagic fever or dengue shock sydnrome
most common hantavirus strain WW; disease manifestation?
hemorrhagic fever and renal syndrome(HFRS)
over 100000 cases in china; 5-10% mortality
most common strain in US and its disease??
hantavirus, sin nombre virus
hantavirus pulmonary syndrome(HPS) - severe pulmonary illness w/fever; acute respiratory distress
transmission of hantavirus
aerosol of urine/feces from rodents
ssRNA(-), helical, enveloped
yellow fever, dengue
hantavirus, lassa virus
yellow fever and dengue - mosquito
hantavirus - rodent urine/feces
lassa - house rat urine/feces
clinical presentation of lassa virus
multi-organ system disease w/fever and hemorrhaging
kinda looks like ebola
leading cause of acute febrile illness in US travelers returning from: carribbean, south america, and asia
viruses causing hemorrhagic fever
yellow fever, dengue (flavi)
lassa virus transmission
human-human spread is possible too
clinical presentation of yellow fever
"black vomit" - hematemesis
Hepatitis(yellow) + hemorrhagic fever
vaccines available for hemorrhagic fever viruses?
just yeloow fever(live-attenuated, effective)
treatment for lassa virus
lassa virus genome
family of lassa virus?