Non-HIV Antiviral Drugs Flashcards Preview

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Flashcards in Non-HIV Antiviral Drugs Deck (18):
1

neuraminidase inhibitor mechanism

neuraminidase(NA) cleaves sialic acid bound to HA(influenza surface protein)

inhibitors are sialic acid analogs that competitively inhibit neuraminidase

  • no release of influeza from cell; cant infect others

2

neuraminidase inhibitors

zanamavir

oseltamavir

3

neuraminidase toxicity

seizure events

respiratory distress

4

indications for neuraminidase therapy

uncomplicated acute influenza in high risk pts

  • children, 65+, pregos

also prophylaxis for high risk children, family members, HC workers taking care of them

5

neuraminidase resistances

cross-resistance occurs due to mutations in influenza receptor and neuraminidase

6

ribavirin mechanism

gets phosphorylated to 5'-MP form via cellular enzyme

inhibits IMP dehydrogenase; stops GMP and eventually AMP synthesis

7

indications for ribavirin

respiratory syncytial virus in kids

parainfluenza

Hep C therapy

....maybe MERS-CoV and SARS

8

ribavirin toxicity

anemia, MI, teratogen

contraindicated for pregos and their husbands

9

standard of care for HCV pts

ribavirin, pegylated IFN

telaprevier and boceprevir are PIs that can be added to improve regimen

better regiments are coming

10

acute HBV therapy; 1st line

entecavir, tenofovir

RT inhibitors

11

durgs inhibiting DNA replication

acyclovir

valaciclovir(prodrug of acyclovir)

famciclovir

ganciclovir

others: idoxuridine, trifulridine, fuorouracil

 

12

acyclovir/valaciclovir mechanism

HSV selective: phosphorylation by viral TK - MP

phosphorylation by cell kinases - DP, TP

  1. selectively inhibits viral DNA polymerase 
  2. incorporates into viral DNA and causes strand termination

13

indications for acyclovir

HSV, VZV, EBV

CMV prophylaxis

14

famciclovir mechanism, cross resistance, indications

same mech as acyclovir, less polymerase inhibition

cross-resistance with acyclovir

approved for genital HSV, VZV

15

ganciclovir mechanism, toxicity, indications

inhibits viral DNA polymerase by chain termination

toxicity: bone marrow suppression and CNS effects

indicated for: CMV in immunosuppressed, pneumonitis in BMT

16

foscarnet mechanism, indications

inhibits viral polymerase at different binding site than acyclovir

inhibits RT as well

indicated for ACV-resistant HSV and CMV retinitis 

17

cidofovir mechanism, indications, toxicity

strand termination

indicated for CMV retinitis

irreversible renal toxicity

18

palivizumab

humanized anit-RSV Mab