Herpes Simplex Viruses Flashcards Preview

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Flashcards in Herpes Simplex Viruses Deck (12):
1

structure of HSV-1/2

type of genome

large(150nm)

enveloped

icosahedral

linear dsDNA - unique UL, US stretches(long and short) flanked by inverted repeats

2

where does HSV1/2 replicate?

where does assembly occur?

both assembly and replication occur IN the nucleus

 

3

how are HSV1/2 transmitted

HSV-1; oral/nasal; (rarely sexual)

HSV-2; genital

4

Disease caused by:

HSV-1

HSV-2

HSV-1

  • gingivostomatitits
  • herpes labialis(cold sores)
  • keratoconjunctivitis
  • encephalitis

HSV-2

  • genital herpes
  • neonatl herpes
  • aseptic meningitis

5

which neural tissues are preferred by HSV1/2 for latency

 

DRG - primarily HSV-2

Trigeminal - primarily HSV-1

6

IE proteins in HSV are activated by what protein contained within the tegument of the original virus?

VP16

allows IE proteins to have transcription activated right away

no wait for proteins to be formed

7

 

areas most commonly affected by HSV-1 vs HSV-2

describe clinical manifestation/visual appearance

clear vesicle on erythematous base progressing to pustular lesions, ulcers

 

HSV-1 = facial

HSV-2 = genital

8

how is neonatal HSV transmitted

describe the manifestation of neonate infection

acquired by passing through birth canal

usually severe disease that extends to CNS/other organs

9

describe mechanism of latency in HSV infections

 

nucleocapsids transport to regional ganglia by retrograde axonal transport

VIral DNA is retained in sensory neurons, only expressing LAT gene

reactivation can occur w/virus transporation back down axon

 

10

ELVIS

enzyme linked virus inducible system

genetically engineered cell line

HSV are plated and when they grow in these cells, galactosidase is produce, staining blue; 

used for early HSV detection

11

HSV DNA in CSF is diagnostic of....

herpes simplex encephalopathy

12

tissues affected by HSV

skin, cornea, CNS