Respiratory Viruses Flashcards Preview

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Flashcards in Respiratory Viruses Deck (29):
1

most common viral cause of bronchiolitis

RSV( and HMPV)

2

has surface protein, F, that fuses w/cell membrane @ neutral pH

replicates in ciliated epithelial cells lining respiratory tract

parainfluenza virus

2

rhinovirus attaches via_____to target cell

induces the production of ______ and ______ to induce vasodilation and inflammation

rhinovirus attaches via ICAM1 to target cell

induces the prodcution of bradykinin and IL8 to induce vasodilation and inflammation

2

complications of flu?

superinfection

increases risk of s.aureus pneumonia and pneumonia in general

3

flu presentation

FEVER, HA, MYALGIA, MALAISE

+ resp symptoms(cough, sore throat)

+-GI symptoms(NVD)

 

4

most susceptible population for bronchiolitis?

risk factors?

neonates/bebes are most at risk; 

 

any abnormal/birthing complications/defects will predispose the child to bronchiolitis;

4

palivizumab

monoclonal Ab prophylaxis for RSV

give to premies/bebes @ high risk

6

most common viral cause of croup

parainfluenza virus

7

CPE for influenza

kills ciliated epithelium in throat

9

internal ribosome entry sites

regions which ribosomes bind to on rhinovirus mRNA to initiate translation

9

why does rhinovirus have nasal specificity

grows better at 33/34C than 37C; colder temps

10

flu season?

winter(october-march)

11

peak season for parainfluenza infections?

FALL OR LATE SPRING

like the common cold...

12

hallmark of croups?

narrowing of subglottic region

steeple sign

13

duration of common cold

 

peak viral growth?

~a week(5-7 days)

 

peak growth @ ~day 3

13

presentation of rhinovirus

nasal mucosa ifection: sneezing, rhinitis, nasal obstruction,sore throat

FEVER UNCOMMON

15

describe pathogenesis of RSV

infects nasopharyns(turbinates) then spreads to lower respiratory tract

causes necrosis of bronchiolar epithelium and destroys epithelial cells

inflammation, mucous, cell debris clog bronchioles

16

peak season for rhinovirus

FALL, LATE SPRING

17

Relavent respiratory viruses(transmited via respiratory droplets)

rhinovirus

parainfluenza

influenza

RSV(and HMPV)

18

peak season for bronchiolitis

october-may - Patel

 

19

most susceptible to flu?

very young and very old

still nasty for anyone

21

most common viral cause of common cold

rhinovirus

23

antigenic drift vs shift for influenza genome

shift is combo of 2 influenza genomes = pandemic

drift is minor changes to genome through mutation as it moves through population

24

describe the genome of influenza

what determines influenza strain?

segmente genome(8 segments); RNA(-)

HA, NA types determine influenza strain

25

describe entry/replication of influenza

  • HA binds sialic acid on surface
  • Enters in endosome
  • endosome acidifies, changing conformation of HA to fuse with endosome membrane;
  • M2 dependent uncoating
  • RNA heads to nucleus for replication/transcription

26

where does influenza virus replicate w/in the cell?

nucleus

27

2nd leading cause of childhood hospitalizations for acute respiratory infections

croups; parainfluenza

28

most common/suscpetible age for croups

pre-school age; dont see it much after age 6

29

SARS-CoV receptor

MERS-CoV receptor

SARS - ACE2; ciliated epithelium

MERS - DPP4; alveorlar