Hepatitis Viruses Flashcards Preview

Virology > Hepatitis Viruses > Flashcards

Flashcards in Hepatitis Viruses Deck (28):
1

cirrhosis is most common in which hepatitis viruses

HBV+-D
HCV

2

structure/genome of hepatitis B virus

enveloped, icosahedral
partially dsDNA

3

what does the HBV dsDNA do upon entering the nucleus

dsDNA becomes cccDNA

cccDNA is fo life; cant get rid of that shit

4

transmission of HBV

sex
parenteral
perinatal(70-90% transmission w/out treatment)

5

child vs adult risk of progressing to chronic HBV

30-90% chance for children <5% chance for healthy adults

6

hepatocarcinoma in HBV vs HCV

due to HBV DNA entering the nucleus, hepatocarcinoma can occur during any time in the disease

for HCV, hepatocarcinoma only occurs after cirrhosis after an extended chronic period

7

values for a resolved HBV patient
HBsAg =
HBsAb =
HBcAb(IgG) =
HBV DNA =

HBsAg = negative
HBsAb = positive
HBcAb(IgG) = positive(acute IgM +)
HBV DNA = negative

8

values for a chronic HBV patient
HBsAg =
HBsAb =
HBcAb(IgG) =
HBV DNA =

HBsAg = positive
HBsAb = negative (probably why its chronic)
HBcAb(IgG) = positive(acute IgM)
HBV DNA = positive

9

values for a patient with HBV vaccine
HBsAg =
HBsAb =
HBcAb(IgG) =
HBV DNA =

HBsAg = negative
HBsAb = positive
HBcAb(IgG) = negative
HBV DNA = negative

10

1st line treatment for HBV patients(liver damage)

tenofovir, entecavir

11

prevention therapy for HBV

indications?

Hep B immunoglobulin
Hep B Vaccine

all children should be vaccinated
immunoglobulin can be given to adverse exposures and/or infants of HBsAg positive mothers

12

key points for HCV life cycle

- no integration into host genome
- non-structural proteins are targets for therapy
- relies on host biosynthetic pathways(ER)
- HCV RNA polymerase is VERY prone to error

13

most common source of transmission for HCV?

parenteral(IDU)
sex(rare)

14

what is the prognosis for HCV?

prognosis is good!
cirrhosis takes a while to come about
there is good treatment for HCV(curable!)

15

% of pt from acute HCV that progress to chronic

% that get cirrhosis from chronic group

85% get chronic HCV

20% get cirrhosis

16

symptom severity in children vs adults for HBV

symptoms are much more mild for children

17

treatment for HCV
indications?

HCV-1,4 = sofosbuvir(NS5A inhibitor)
HCV2,3 = sofosbuvir + ribavirin(12wk for 2, 24wk for 3)

18

SVR

sustained virologic response

aviremia(undetectable) following HCV treatment

19

Heptatitis A transmission

fecal-oral(OYSTERS)
blood exposure(rare)

20

describe the prognosis/clinical features of hepatitis A infections

discrete onset
jaundice, elevated liver enzymes, dark urine, etc
virus is shed in stool
99% recover; NO CHRONIC FORM

21

vaccines are avaiable for which hepatitis viruses

Hep B, Hep A

22

prophylaxis for Hep A exposure

passive immunization(up to 2 weeks after exposure)

23

hepatitis E structure/genome

naked icosahedral RNA virus

24

transmission of hepatitis E

fecal-oral

25

significance of hepatitis E

high mortality in pregos
chronic form reported in liver transplant patients

26

what is required for Hep D infections

HBV co-infection OR HBV infeciton presence for superinfection of HDV

27

significance of HDV superinfeciton?

HDV superinfected patients have a worse prognosis; more likely to have fulminant liver disease in acute phase, more likely to progress to cirrhosis

28

most common population getting HDV infections on top of HBV?

IDUs