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Flashcards in Hepatobillary PPT-Josh Deck (77)
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1

this is my last ppt for this test I am going to go through it and only grab the highlights!!!


I cant look at this shit anymore

2


what is the largest solid organ in the body?


liver

3


Liver:

is made up of 50,000-100,000 discrete anatomic units called what?

 


lobules

4


Liver:

how many portal tracts are there?


4-5

5


what are the 2 types of cells that line the sinusoids?


endothelial

kupffer cells (macrophages)

6


Hepatic blood flow:

dual afferent blood supply equal to __% of CO


25%

7


Hepatic blood flow:

70% of blood is spplied via the ____

 


Portal vein

8


Hepatic blood flow:

30% suppied via the _______


hepatic artery

9


Hepatic blood flow:

is how many ml/min


1500 mL/min

10


Hepatic blood flow:

arterial flow is autoregulated based on what?


O2 consumption

11


Hepatic blood flow:

a decrease in either hepatic arterial or portal venous flow results in what?


compensatory increases in the other

12


what is teh normal hepatic blood volume?


450 mL

13


Fuctions of LIver?

Reservoir

Blood cleansing

metabolic

14


Blood cleansing fx:

blood from the gut contains large amounts of colonic bacilli, cleansing is performed by the ___ cells that line the hepatic sinus


Kupffer cells

15


____ cells lint the hepatic sinuc and permit diffusion of large plasma proteins and other substances into extravascular spaces in the liver, resulting in a large quanity of lymph that is nearly equal in protein concentration to plasma


endothelial

16


Metabolic Functions of liver

what re the 4 main metabolic fxns?

 

  1. Carbohydrate metabolism
  2. Fat metabolism
  3. Protein metabolism
  4. Drug metabolism

17


Metabolic Functions of liver

what are the 3 ways the liver does carbohydrate metabolism

 

 

  1. Gylcogenesis
    • process of glycogen synthesis
  2. Glycogenolysis
    • Release of glucose form glycogen
  3. Gluconeogenesis
    • Conversion of fats/proteins to glucose

18


Metabolic Functions of liver

what are the final products of Carbohydrate metabolism


glucose

frutose

galactose

19


Metabolic Functions of liver

what are the 2 ways of fat metabolism

 

  1. Lipogenesis
    • synthesis of cholesterol and proteins and carbs from fat
  2. Lipolysis
    • breakdown of lipids

20


Metabolic Functions of liver

how does it do protein metabolism

 

  • Deamination of proteins
  • Deamination of excess amino acids
  • Synthesis of lipoproteins

21


Metabolic Functions of liver

how does it do Drug metabolism


phase I and II biotransformation

22


Metabolic Functions of liver

what are the vitamins it stores?


A,D,E,K

23


Metabolic Functions of liver

the liver does synthesis of coagulation factors and inhibitors, in fact it does most all clotting factors except???


Factor VIII

24


Metabolic Functions of liver

how it is responsible for phagocytosis?


filtration and destruction of bacteria and debris in blood

25


Metabolic Functions of liver

what minerals is it responsible for?


iron hemostasis

copper regulation

26


LFTs:

normal Albumin


3.5-5.5 g/dL

27


LFTs:

normal AST

10-40 U.mL

28


LFTs:

normal ALT


5-35 U.mL

29


LFTs:

normal Alk phosphate


45-115 u/L

30

what is an inflammatory disease of the liver parenchyma

 


Hepatitis