What is the most abundant cell in the body
25 trillion cells (thats kinda badass)
What s teh main function of erythrocytes
oxygen delivery to tissues
erythrocytes are biconcave disk, what the fuck does that mean?
ability to change shape
increases surface area
what is the main function
- Transport Hgb for O2 delivery to tissue
besides carring Hgb, RBCs also containa large amount of what?
Bone marrow (vertebrae, sternum, ribs, pelvis, proximal ends of humerus and femur)
RBC production is controlled by what?
- the ability to transpot O2 to the tissues
what cell or enzyme or whatever is responsible for producing RBCs
what 2 vitamins are required for RBC production
- B12 (cyanocalamin)
- Folic acid
120 days after leaving bone marow
what is the protein-iron compound in the RBC?
what is Hgb for
allows RBCs to transport O2
what is the ratio of packed RBCs to total blood volume?
male- 13.9-16.3 g/dL
Female 12-15 g/dL
what is normal Hct levels
what is the total number of RBCs in a sample of blood
Females- 3.5-5.5 x10^6
what is a measurement of the average size of the RBC, and indicated whether the RBC is small, large, or normal?
Mean Corpuscular Volume
what is the concentration of Hgb in a given volume of blood?
Mean Corpuscular hemoglobin concentration
explain the Hgb molecule (just basic)
- 2 alpha
- 2 Beta
- each chain has a heme group
- each heme group has an iron molecule
what is a reduction in the total number of circulating erythrocytes or a decreased in the quantity or quality of hemoglobin
the WHO defines anemia as less than ___g/dL of Hgb for men and less than ___g/dL of Hgb for women
postoperatively up to ___% of pts are anemic
___% of pts over 65 are anemic
___to ____ of pts preop are anemia
3 main causes
- Impaired RBC production
- Blood loss (aucte/chronic)
- Increased RBC destruction
is classified according to what?
morphology (size, shape, hgb coontent)
is classified as "-cytic" indicates what type of enemia
refers to cell size
if classified as "-Chromic" it indicated what
referes to Hgb content
so if classified as Normocytic or normochromic, it indicates what?
normal RBC volume and normal Hgb content
so if classified as Macrocytic or Hyperchromic what deos that mean
High RBC volume and High Hgb content