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Flashcards in Anemia PPT -Josh Deck (101)
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1


What is the most abundant cell in the body

Erythrocytes

25 trillion cells (thats kinda badass)

2


What s teh main function of erythrocytes


oxygen delivery to tissues

3


erythrocytes are biconcave disk, what the fuck does that mean?


ability to change shape

increases surface area

4


Erythrocytes (RBC):

what is the main function

 

  1. Transport Hgb for O2 delivery to tissue

5


Erythrocytes (RBC):

besides carring Hgb, RBCs also containa  large amount of what?


Carbonic anhydrase

6


Erythrocytes (RBC):

Produced where?


Bone marrow (vertebrae, sternum, ribs, pelvis, proximal ends of humerus and femur)

7


Erythrocytes (RBC):

RBC production is controlled by what?

 

  • the ability to transpot O2 to the tissues

8


Erythrocytes (RBC):

what cell or enzyme or whatever is responsible for producing RBCs


erythropoietin

9


Erythrocytes (RBC):

what 2 vitamins are required for RBC production

 

  • B12 (cyanocalamin)
  • Folic acid

10


Erythrocytes (RBC):

life span


120 days after leaving bone marow

11


Erythrocytes (RBC):

what is the protein-iron compound in the RBC?


Hgb

12


Erythrocytes (RBC):

what is Hgb for


allows RBCs to transport O2

13


Erythrocytes (RBC):

what is the ratio of packed RBCs to total blood volume?


Hct

14


Erythrocytes (RBC):

Normal Hgb


male- 13.9-16.3 g/dL

Female 12-15 g/dL

15


Erythrocytes (RBC):

what is normal Hct levels


Male- 39-55%

Female- 36-48%

16


Erythrocytes (RBC):

what is the total number of RBCs in a sample of blood


RBC count

normal values

male-4.3-5.9 x10^6

Females- 3.5-5.5 x10^6

17


Erythrocytes (RBC):

what is a measurement of the average size of the RBC, and indicated whether the RBC is small, large, or normal?


MCV

Mean Corpuscular Volume

18


Erythrocytes (RBC):

what is the concentration of Hgb in a given volume of blood?


MCHC count

Mean Corpuscular hemoglobin concentration

19


Erythrocytes (RBC):

explain the Hgb molecule (just basic)

 

  • 4 chians
    • 2 alpha
    • 2 Beta
  • each chain has a heme group
  • each heme group has an iron molecule

20


Erythrocytes (RBC):

what is a reduction in the total number of circulating erythrocytes or a decreased in the quantity or quality of hemoglobin


Anemia

21


Erythrocytes (RBC):

the WHO defines anemia as less than ___g/dL of Hgb for men and less than ___g/dL of Hgb for women


13

12

22


Erythrocytes (RBC):

postoperatively up to ___% of pts are anemic


80%

23


Erythrocytes (RBC):

___% of pts over 65 are anemic


75%

24


Erythrocytes (RBC):

___to ____ of pts preop are anemia


1/3-1/2

25


Anemia:

3 main causes

 

  1. Impaired RBC production
  2. Blood loss (aucte/chronic)
  3. Increased RBC destruction

26



Anemia:

is classified according to what?


morphology (size, shape, hgb coontent)

27



Anemia:

is classified as "-cytic" indicates what type of enemia


refers to cell size

28



Anemia:

if classified as "-Chromic" it indicated what


referes to Hgb content

29



Anemia:

so if classified as Normocytic or normochromic, it indicates what?


normal RBC volume and normal Hgb content

 

30



Anemia:

so if classified as Macrocytic or Hyperchromic what deos that mean


High RBC volume and High Hgb content