seminiferous, open, euchromatic -nucleolus
“checkerboard” nucleus, middle layer
low back pain, urethral discharge, fever. Expressed prostatic secretions (EPS) culture
CT that divides testis into lobules
the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.
tumors that arise from sustentacular cells or interstitial cells
Sex cord-stromal tumors
Testis dense CT capsule
inflammatory response within IT of testis (e.g., viral mumps in adults, syphilis)
Orchitis - scarring may cause infertility, T production often not significantly affected
Semiferous epithelium, 3 layers
Seminiferous (germinal) epithelium, basement membrane, tunica propria
nuclei along the BM
Found from transitional zone. Associated with DHT, stromal cells convert T to DHT, dysuria, secondary UTIs (urine retention)
Benign prostatic hyperplasia (BPH)
have the appearance of a mucus-secreting gland. lubricates the urethra with pre-seminal mucus
produce testosterone (T)
interstitial cells (of Leydig)
defining histologyical feature of prostate gland
testis are responsible for…
spermatogenesis: exocrine (holocrine) secretion of sperm AND steroidogenesis: endocrine secretion of testosterone
yield primary spermatocytes by mitosis…
disruption of the B-T barrier, antisperm antibodies (ASA)
The seminiferous tubules are formed from…
primitive sex cords. It is the medullary cords which develop into the seminiferous tubules and the cortical cords regress. The cords were formed from the gonadal ridge.
Interstitial tissue (IT) loose connective tissue stroma that contains…
fenestrated capillaries, interstitial cells (of Leydig): produce testosterone (T)
Tumors that arise from spermatogenic cells;
Germ cell tumors, most common (95%).
regulates glandular epithelium growth and metabolism
Prostatic acid phosphatase (PAP)
small, dark nucleus, near lumen
produce ABP, MIS, inhibin, fructose-rich fluid
sustentacular (Sertoli) cells
days until the effects of an antispermatogenic agent are fully observable
86 days, 74 in testis, 12+ to mature in epididymis
Formed by tight junctions between sustentacular cells
Blood-testis barrier. Sequesters testosterone in luminal compartment -necessary for spermatogenesis. Gap junctions coordinate activity.
Seminiferous tubules epithelium
sustentacular or Sertoli cells, which are tall, columnar type cells that line the tubule.
primary spermatocyte divides meiotically into …
two secondary spermatocytes. Each secondary spermatocyte then completes meiosis as it divides into two spermatids which developninto mature spermatozoa (sperm cells).
Seminiferous (germinal) epithelium:
spermatogenic cells and sustentacular cells
most resistant to BPH, prostatitis, & cancer