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Immuno Block Mid Term 1 > Humoral Immunity B Cells > Flashcards

Humoral Immunity B Cells Flashcards

1
Q

Are B cells APCs?

A

yes! they can ingest protein antigens degrade them into peptides and display with MHC II for cd4 cells

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2
Q

stimulators of IgM synthesis

A

polysaccharides and lipids stimulate the production of IgM

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3
Q

Where is IgM found on B cells?

A

on the surface, it is the antibody that resided on surface to attach lipids and polysaccharide

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4
Q

stimulators of IgG IgA and IgE antibodies

A

peptide antigens noticed by CD4 cells lead to induction of production of these

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5
Q

B cell maturation cell lineage

A 
stem cell
Pro-B
Pre-B
Immature B
Mature B
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6
Q

Ig expression in Pre-B lymphocyte cells

A

is in the cytoplasm

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7
Q

Ig expression in immature B lymphocyte cells

A

membrane now has IgM

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8
Q

Ig expression in mature B lymphocyte cells

A

have IgM and IgD on membrane

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9
Q

Where does clonal expansion of B cells occur?

A

in the lymph nodes or spleen!

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10
Q

Fc and Fab regions of antibodies

A

Fab regions are antigen binding

Fc regions are not antigen binding

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11
Q

What cells bind at Fc region of antibody?

A

macrophages, neutrophils NK cells, mast, basophils eosinophils

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12
Q

IgA locations and function

A

on body surfaces to protect from outside foreign pathogens

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13
Q

IgG locations and function

A

found in all body fluids

most common antibody
fight bacterial and viral infections

only antibody that can cross into placenta

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14
Q

IgM locations and function

A

found in the lymph and blood

first antibody made in response to an infection

pentamer, large,

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15
Q

IgE locations and function

A

found in lungs skin and mucous membranes

involved in allergic reactions

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16
Q

IgD location and function

A

found on the cell surface of newly synthesized B cells

just a cell surface receptor

17
Q

Antibodies for neutralization?

A

IgG and IgA

18
Q

Antibody for opsonization?

A

IgG

19
Q

Antibodies for complement activation?

A

IgM is best and some IgG

20
Q

Antibody for transport across epithelium?

A

IgA

21
Q

Antibody for diffusion into extravascular sites?

A

IgG is best

22
Q

Antibody with highest serum level?

A

IgG

23
Q

3 types of mature B cells?

A

follicular B cells
marginal zone B cells
B-1 lymphocytes

24
Q

follicular B cells location and function

A

in the follicles of spleen and in lymph nodes

can isotype switch, high affinity antibodies produced, long lived plasma cells

25
Q

Marginal zone B cells location and function

A

in the marginal zone of splenic follicles

make IgM and have short loved plasma cells

26
Q

B-1 cells location and function

A

peritoneal cavity and lymphoid organs and mucosal tissue

makes IgM and short lived plasma cells

27
Q

antibody isotype in first compared to second exposure?

A

in first there will be a lot of IgM and then in second there will be more IgG

28
Q

What is C3d and what is its role in B cell activation?

A

c3d is the breakdown product of c3b from complement

it will bind the Cr2/cd21 receptor on B cells and help activate them when an antigen is attached to its membrane antibody

29
Q

Do B cells have TLRs? What is function?

A

yes they have them so they can recognize microbial products…it is a linkage between the innate and adaptive immunity

30
Q

How do CD4 cell interacts with B cells

A

they bind the MHC class II peptides on the B cell

31
Q

What is made by CD4 cells to help B cells proliferate?

A

cytokines and CD40

32
Q

germinal center of a lymph node function

A

activated B and cd4 T cells come back to a follicle in the lymph node and cause proliferation of the B cells,..which is the germinal center

in the germinal center there is a lot of class switching anf somatic mutations for the antibodies

33
Q

steps of B cell activation and proliferation in a lymph node….

A
  1. CD4 T cell is activated and B cell is activated and goes to the extrafollicular space
  2. The effector CD4 cell interacts with a B cell and stimulates it in an extrafollicular space
  3. B cell starts to make short lived plasma cells
  4. short lived plasma cells and the CD4 T cell go back into a follicle
  5. the plasma cells and T cells stimulate the follicle B cells to start proliferating and maturing
34
Q

cytokine inducing switch to IgG antibodies? What T Cell?

A

Interferon gamma

Th1

35
Q

cytokine inducing switch to IgE antibodies? What T cell?

A

IL-4

Th2

36
Q

cytokine inducing switch to IgA antibodies? What T cell?

A

cytokines in mucosal tissues like TGF-beta and BAFF

Th17

Immuno Block Mid Term 1 (16 decks)

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