Adaptive Overview Flashcards
humoral immunity cells and what is it best fighting against?
B cells are responsible, uses antibodies, plasma cells,
best against exctracellular microbes and toxins
cell-mediated immunity cells and what is best at fighting?
mediated by T cells
intracellular pathogens like virals and also phagocytosed microbes that survive (TB)
b lymphocyte functions
neutralize and enrich phagocytosis and activates the classical component pathway
helper t lymphocyte function
activate macrophages, inflammation, and activates and proliferates B and T cells
uses cytokines to complete these functions
cytotoxic T cells function
kill infected cells
Regulatory T cell function
suppress the immune response
peripheral lymphoid organs for lymphocytes
spleen, lymph nodes, mucosal and cutaneous lymphoid tissue
naive lymphocytes growth
recognize an antigen and initiates adaptive immune response, then needs signals in addition to the antigen to proliferate and differentiate effector cells
effector cells of lymphocytes
B cells…plasma cells
CD4 t cells are cytokine producers (t helpers)
CD8 t cells….cytotoxic t cells
memory T lymphocytes location and activity
one subset in lymph nodes and another subset in mucosa and inflamed tissues
has no activity
memory B lymphocytes immunoglobulin and function and affinity
IgG, IgE, and IgA
no function
high affinity
naive B cell immunoglobulin and function and affinity
IgM, IgD
no function
low affinity
active B cell immunoglobulin function and affinity
IgG, IgE, and IgA
secretes antibodies
increasing affinity
IgA antibody function
most common antibody
mucosal immunity
IgD antibody function
small amounts in serum
naive B cell antigen receptor
