Immuno Flashcards Preview

Ed's One Liners / EMQ Buzzwords > Immuno > Flashcards

Flashcards in Immuno Deck (63):
1

Low B-cell count + Low IgA, IgM, IgG

Bruton's agammaglobulinaemia

2

Cleft lip / palate, hypocalcaemia, low T-cell count (+ cardiac abnormalities / thymic aplasia)

Di George's syndrome (CATCH symptoms)

22q11 deletion

3

Reduced IgM and raised IgA + IgE.

Clinically: Eczema / nosebleeds / bruising

Wiskott-Aldrich syndrome

4

Mutation of MHC III + mild pneumonia

Common variable immunodeficiency

5

Jaundice + hepatomegaly + sclerosing cholangitis with a defect in either MHC I (CD8+ T cells) or MCH II (CD4+ T Cells)

Bare lymphocyte syndrome

6

Anti-cyclic citrullinated protein

Rheumatoid arthritis

7

Anti-smooth muscle antibodies

autoimmune hepatitis / PSC

8

Anti-Jo1

Dermatomyositis

9

Anti-centromere

Limited systemic scleroderma (CREST syndrome)

10

Anti-topoisomerase

Diffuse systemic scleroderma (more aggressive than limited systemic scleroderma (CREST)).

Pulmonary Fibrosis is defining feature

11

Anti-Ro + Anti-La

Present in 50% of Sjogren's patients

12

Anti-glutamic acid decarboxylase

Type 1 Diabetes Mellitus

13

'Saddle-shaped' nose

Wegner's granulamatosis (Granulomatosis with polyangiitis (GPA))

14

Anti-endomysial

Ceoliac

15

CSF demonstrates oligoclonal bands of IgG on electrophoresis

Multiple Sclerosis (MS)

16

Western blot test

HIV

17

Kveim Test

Sarcoidosis

18

Direct antiglobulin test (DAT) (aka Direct Coombs test)

Autoimmune haemolytic anaemia (AIHA)

19

Skin prick test

Hypersensitivity reactions e.g. peanuts

20

Recurrent mild pneumonias / diarrhoea but otherwise fine

Selective IgA deficiency

21

CTL4- immunoglobulin fusion protein

Abatacept (used in long-standing rheumatoid arthritis)

22

Anti-TNF α

Infliximab

23

Drug - prevents guanine synthesis and induces immunosuppression

Mycophenolate mofetil

24

HLA DQ2

Coeliac

25

HLA B27

Ankylosing spondylitis

26

HLA DR2

Goodpasture's syndrome

27

HLA DR3

Graves', SLE, Myasthenia gravis

28

HLA DR4

T1DM, rheumatoid arthritis

29

NEGATIVE nitro-blue-tetrazolium (NBT) test (remains colourless)

Chronic granulomatous disease

30

C1, C2, C4 deficiency

SLE

31

Anti-GBM antibodies

Goodpasture's

32

Anti-Ach receptor

Myasthenia Gravis

33

Desmoglein 3

Pemphigus vulgaris

34

Desmoglein 1

Pemphigus foliaecus

35

Anti-voltage gated soidum channels

Lambert-Eaton (opposite of Myasthenia Gravis)

36

Opiate overdose

Naloxone

37

Aspirin / salicylates overdose

Activated charcoal or haemodialysis if >1 hour

38

Organophosphates poisoning

Atropine

39

CEA (Carcino Embryonic antigen)

Colorectal cancer

40

Mutation in alpha-synuclein protein

Familial Parkinsons

41

'Can't see, pee or climb a tree'

Reactive arthritis / Reiter's syndrome

42

Old man, bone pain, raised ALP

Paget's

43

Hereditary angioedema deficiency

C1 inhibitor esterase

44

Potential genetic defect contributing to atopic dermatitis

Filaggrin mutation

45

Irritability + neutrophils

Kostmann Syndrome (severe congenital neutropenia)

46

How to monitor activity of SLE?

C3 + C4 levels

47

Antibody used to diagnose someone with systemic sclerosis

Anti-SCL-70

48

Treatment for Wegners

Cyclophosphamide

49

Rheumatoid Arthritis DMARDS / Biologics

Start on anti-TNF alpha i.e. Etanercept, Adalimumab, infliximab.

Move on to tocilizumab (anti-IL 6)

50

DMARD used in Psoriasis

Ustekinemab (anti IL-12 / IL-23)

51

DMARD used in CGD

IFN-gamma

52

How to treat Hereditary angioedema

1. Patient can talk

2. Patient can't talk

1. IV C1 inhibitor

2. Tracheostomy

53

HIV:

Neutralising antibodies are formed against which glycoprotein

gp120

54

HIV:

Non-neutralising antibodies are formed against which protein

p24

55

Co-receptors required for HIV entry into cells

CCR5 or CXCR4

56

6-month old boy with severe failure to thrive and recurrent infections.

T-cells undetectable
B-cells normal

SCID

57

CD40L deficiency AKA...

Hyper-IgM

58

What complements make up thr membrane attack system?

C5b, C6, C7, C8, C9

59

CD found on activated T-cells, binds to IL-2

CD25

60

Hep B Blood test - Positive following vaccination or previous infection

Anti-HBs

61

Hep B Blood test - Positive in all Hep B carriers

HBsAg

62

Hep B Blood test - Antigen which is positive in carriers with HIGH infectivity

HBeAG

63

Hep B Blood test - Positive following previous infection but not following vaccination

Anti-HBc (c = caught)