Influenza Flashcards Preview

Jason's Respiratory Block > Influenza > Flashcards

Flashcards in Influenza Deck (77)
Loading flashcards...
1

How does chest x-ray look with seasonal flu?

normal

2

how long does acute infection of seasonal flu?

7 days, cough lasts a few weeks

3

at risk groups for seasonal flu?

young, old

4

incubation (days) of seasonal flu?

1-5 days

5

infectiousness of seasonal flu (days)??

5-6 days

6

deaths worldwide from seasonal flu?

1/4 to 1/2 MILLION

7

Influenza binds to what on non-ciliated respiratory epithelium?

sialic acid sugar

8

What kind of linkage on the sialic acid is it to galactose?

alpha 2-6

9

Flu spreads from infection site?

Nope. Localized.

10

Which airways does influenza like to replicate?

larger airways

11

what cytokine causes malaise, head and muscular aches?

IFNs

12

What cytokine causes fever?

IL-1

13

where is ciliated epithelium in respiratory system?

trachea and bronchi

14

Do you normally get viral pneumonia with flu?

Nope, usually due to secondary bacterial infections after cilia destruction

15

Influenza have envelopes?

Yes

16

Influenza and Rotavirus has what kind of genome?

single stranded -ve sense RNA

17

T/F?Influenza B can infect other species but only A is humans

False. B infects humans only, A infects other species

18

Influenza C is a major problem these days?

Naw. minor pathogen bro.

19

HA and NA for Influenza stands for?

haemagglutinin
Neuraminidase

20

What does NS1 the non-structural protein in Influenza do?

anti-interferon activity

21

how man gene segments in Influenza? encodes how many proteins?

8 segments encode 10+ proteins

22

how many polymerase subunits does Influenza come packaged with per RNP?

3

23

What is RNP in Influenza?

Ribonucleoproteins

24

HA is the snipper in Influenza?

Nope, the gripper

25

NA is the gripper or snipper in Influenza?

snipper

26

How many subtypes of HA and NA do we know of for Influenza?

17 HA
9NA

27

how many subtypes of HA and NA are there for Influenza B?

Only ONE.

28

What are the ancestral hosts of Influenza A?

aquatic birds

29

Current Influenza A subtypes in humans are?

H1N1
H3N2

30

How is Influenza taken into the cell?

receptor mediated endocytosis