Flashcards in Influenza Deck (77)
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1
How does chest x-ray look with seasonal flu?
normal
2
how long does acute infection of seasonal flu?
7 days, cough lasts a few weeks
3
at risk groups for seasonal flu?
young, old
4
incubation (days) of seasonal flu?
1-5 days
5
infectiousness of seasonal flu (days)??
5-6 days
6
deaths worldwide from seasonal flu?
1/4 to 1/2 MILLION
7
Influenza binds to what on non-ciliated respiratory epithelium?
sialic acid sugar
8
What kind of linkage on the sialic acid is it to galactose?
alpha 2-6
9
Flu spreads from infection site?
Nope. Localized.
10
Which airways does influenza like to replicate?
larger airways
11
what cytokine causes malaise, head and muscular aches?
IFNs
12
What cytokine causes fever?
IL-1
13
where is ciliated epithelium in respiratory system?
trachea and bronchi
14
Do you normally get viral pneumonia with flu?
Nope, usually due to secondary bacterial infections after cilia destruction
15
Influenza have envelopes?
Yes
16
Influenza and Rotavirus has what kind of genome?
single stranded -ve sense RNA
17
T/F?Influenza B can infect other species but only A is humans
False. B infects humans only, A infects other species
18
Influenza C is a major problem these days?
Naw. minor pathogen bro.
19
HA and NA for Influenza stands for?
haemagglutinin
Neuraminidase
20
What does NS1 the non-structural protein in Influenza do?
anti-interferon activity
21
how man gene segments in Influenza? encodes how many proteins?
8 segments encode 10+ proteins
22
how many polymerase subunits does Influenza come packaged with per RNP?
3
23
What is RNP in Influenza?
Ribonucleoproteins
24
HA is the snipper in Influenza?
Nope, the gripper
25
NA is the gripper or snipper in Influenza?
snipper
26
How many subtypes of HA and NA do we know of for Influenza?
17 HA
9NA
27
how many subtypes of HA and NA are there for Influenza B?
Only ONE.
28
What are the ancestral hosts of Influenza A?
aquatic birds
29
Current Influenza A subtypes in humans are?
H1N1
H3N2
30
