Intestinal Neoplasmas Flashcards Preview

Unit 6: Pathology > Intestinal Neoplasmas > Flashcards

Flashcards in Intestinal Neoplasmas Deck (10):
1

What is Peutz Jeghers syndrome?

inactivating mutation of LKB1
-intestinal hamartomatous polyps and freckle like macular lesions which fade at puberty

2

Which cancers does Peutz jeghers syndrome predispose someone to?

breast, pancreas, testis, ovary

3

Where in the small intestine would adenocarcinomas occur?

duodenum and jejunum

4

What diseases inc risk for adenocarcinoma of the small intestine?

-crohn disease
-FAP
-HNPCC
-Lynch syndrome
-Celiac disease

5

Compare and contrast mediterannean vs western type intestinal lymphoma?

-both originate in nodules of MALT

Mediterranean:
-poor countries in young men
-duodenum and proximal jejunum

Western
-adults older than 40, kids <10
-immunosuppression inc risk
-ileum

6

Where is the most common location of a carcinoid tumor?

appendix

7

Where is the location that a carcinoid tumor is known to be most aggressive?

ileum

8

When would carcinoid syndrome be present with a carcinoid tumor?

ONLY when metastasis present in the liver
-otherwise 5H1AA is not secreted
(liver has MAO to breakdown serotonin)

9

What are the symptoms of carcinoid syndrome?

bronchospasm, diarrhea, flushing of the skin
Right sided valvular fibrosis of the heart
-tricuspid regurg and pulm valve stenosis

10

What is the most common neoplasm of the small intestine?

metastatic tumors
-lung, female genital organs, melanomas